Immunoreactive hepatocyte growth factor is a strong and independent predictor of recurrence and survival in human breast cancer.
Immunoreactive hepatocyte growth factor is a strong and independent predictor of recurrence and survival in human breast cancer.
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发表时间：
1994-04
期刊：
影响因子：
11.2
通讯作者：
J. Yamashita;M. Ogawa;S. Yamashita;K. Nomura;M. Kuramoto;T. Saishoji;Sadahito Shin
中科院分区：
文献类型：
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作者：
J. Yamashita;M. Ogawa;S. Yamashita;K. Nomura;M. Kuramoto;T. Saishoji;Sadahito Shin
肝细胞生长因子（HGF）是一种基质衍生的上皮细胞增殖和运动的调节剂。在本研究中，我们已经测量了免疫反应（IR）-HGF浓度的肿瘤提取物中的258原发性乳腺癌使用酶联免疫吸附试验，并评估其与无病生存和总生存。ir-HGF浓度的中位数为11.0 ng/100 mg蛋白（范围：1.4-566.7 ng/100 mg蛋白）。ir-HGF浓度与临床病理因素的相关性分析显示，ir-HGF浓度仅与肿瘤大小相关（P = 0.05）。未发现ir-HGF含量与年龄、绝经状态、淋巴结状态、组织学类型、组织学分级、血管受累、雌激素受体、孕激素受体、手术类型或术后辅助治疗之间存在显著相关性。在另一组82例患者中，与ir-HGF浓度较低的患者相比，ir-HGF浓度较高的乳腺癌患者的无复发率（P = 0.001）和总生存率（P = 0.001）明显较短，其临界点为21.7 ng/100 mg蛋白。在多变量分析中，发现ir-HGF水平是预测无复发和总生存率的最重要的独立因素，其重要性大于淋巴结受累。HGF在乳腺癌生长和转移中的假定作用由此得到加强。
Hepatocyte growth factor (HGF) is a stromally derived modulator of epithelial cell proliferation and motility. In the present study, we have measured immunoreactive (ir)-HGF concentration in tumor extracts of 258 primary human breast cancers using an enzyme-linked immunosorbent assay and have evaluated its association with disease-free and overall survival. The median value of ir-HGF concentration was 11.0 ng/100 mg protein (range, 1.4-566.7 ng/100 mg protein). Correlation analyses between ir-HGF concentration and clinicopathological factors showed that the ir-HGF level was correlated only with tumor size (P = 0.05). No significant associations were found between ir-HGF content and age, menopausal status, nodal status, histological type, histological grade, vessel involvement, estrogen receptor, progesterone receptor, type of surgery, or postoperative adjuvant therapy. Breast cancer patients with high ir-HGF concentration had a significantly shorter relapse-free (P = 0.001) and overall survival (P = 0.001) rate when compared to those with low ir-HGF concentration at the cutoff point of 21.7 ng/100 mg protein, which was determined in another group of 82 patients. In multivariate analysis, ir-HGF level was found to be the most important independent factor in predicting relapse-free and overall survival, of greater import than lymph node involvement. The putative role of HGF in breast cancer growth and metastasis is hereby strengthened.