Wireless Recording in the Peripheral Nervous System with Ultrasonic Neural Dust
Wireless Recording in the Peripheral Nervous System with Ultrasonic Neural Dust
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DOI：
10.1016/j.neuron.2016.06.034
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发表时间：
2016-08-03
期刊：
影响因子：
16.2
通讯作者：
Maharbiz, Michel M.
中科院分区：
文献类型：
--
作者：
Seo, Dongjin;Neely, Ryan M.;Maharbiz, Michel M.
生物电子医学的新兴领域寻求破译和调节体内电生理活动的方法，以达到靶器官的治疗效果。目前与周围神经和肌肉连接的方法严重依赖电线，这给长期使用带来了问题，而新兴的无线方法缺乏询问小直径神经所需的尺寸可扩展性。此外，传统的基于电极的技术缺乏以高空间分辨率记录神经或独立记录神经束内许多离散部位的能力。在这里，我们展示了神经尘埃，一种无线且可扩展的超声波反向散射系统，用于为植入的生物电子设备供电和通信。我们证明超声波可以有效地为组织中的毫米级设备提供电力；同样，使用反向散射的无源无电池通信可以高保真地传输麻醉大鼠的肌电图 (EMG) 和神经电图 (ENG) 信号。这些结果凸显了基于超声的神经接口系统在推进未来基于生物电子学的疗法方面的潜力。
The emerging field of bioelectronic medicine seeks methods for deciphering and modulating electrophysiological activity in the body to attain therapeutic effects at target organs. Current approaches to interfacing with peripheral nerves and muscles rely heavily on wires, creating problems for chronic use, while emerging wireless approaches lack the size scalability necessary to interrogate small-diameter nerves. Furthermore, conventional electrode-based technologies lack the capability to record from nerves with high spatial resolution or to record independently from many discrete sites within a nerve bundle. Here, we demonstrate neural dust, a wireless and scalable ultrasonic backscatter system for powering and communicating with implanted bioelectronics. We show that ultrasound is effective at delivering power to mm-scale devices in tissue; likewise, passive, battery-less communication using backscatter enables high-fidelity transmission of electromyogram (EMG) and electroneurogram (ENG) signals from anesthetized rats. These results highlight the potential for an ultrasound-based neural interface system for advancing future bioelectronics-based therapies.