Spreading depression enhances human neocortical excitability in vitro
Spreading depression enhances human neocortical excitability in vitro
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DOI：
10.1111/j.1468-2982.2008.01556.x
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发表时间：
2008-05-01
期刊：
影响因子：
4.9
通讯作者：
Gorji, A.
中科院分区：
文献类型：
--
作者：
Berger, M.;Speckmann, E-J;Gorji, A.
皮质扩散性抑制(CSD)在有先兆的偏头痛中起作用。然而，关于CSD在人类大脑皮层中的神经元效应的研究很少。因此，在本研究中，我们观察了CSD对癫痫患者脑片中场兴奋性突触后电位(FEPSP)和长时程增强(LTP)的影响。在短暂抑制期后，CSD显著增加fEPSP的幅度，并增加新皮质第三层组织LTP的诱导。这些结果表明，CSD促进了人新皮质组织中突触的兴奋性和有效性，这可能是偏头痛患者新皮质组织过度兴奋的原因之一。
Cortical spreading depression (CSD) plays a role in migraine with aura. However, studies of the neuronal effects of CSD in human cortex are scarce. Therefore, in the present study, the effects of CSD on the field excitatory postsynaptic potentials (fEPSP) and the induction of long-term potentiation (LTP) were investigated in human neocortical slices obtained during epilepsy surgery. CSD significantly enhanced the amplitude of fEPSP following a transient suppressive period and increased the induction of LTP in the third layer of neocortical tissues. These results indicate that CSD facilitates synaptic excitability and efficacy in human neocortical tissues, which can be assumed to contribute to hyperexcitability of neocortical tissues in patients suffering from migraine.