3D geometric reconstruction of thoracic aortic aneurysms.
3D geometric reconstruction of thoracic aortic aneurysms.
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DOI：
10.1186/1475-925x-5-59
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发表时间：
2006-11-02
影响因子：
3.9
通讯作者：
Xu XY
中科院分区：
文献类型：
--
作者：
Borghi A;Wood NB;Mohiaddin RH;Xu XY
胸主动脉瘤（TAA）是一种涉及胸主动脉中主动脉直径扩张的病理，导致破裂风险。最近的研究表明，受胸主动脉几何形状和是否存在血栓影响的内壁应力是比最大直径（当前的临床标准）更可靠的破裂预测指标。TAA几何形状的准确重建是患者特定应力计算的关键步骤。在这项工作中，开发了一种新的方法，该方法结合了来自多组具有不同细节水平和不同分辨率的磁共振（MR）图像的数据。采用两组图像创建最终模型，该模型具有动脉瘤每个组件（管腔、血栓和壁）的最高详细程度。通过使用单组图像进行比较来构建参考模型。该方法应用于胸降主动脉中的两例患者特异性TAA。有限元模拟结果显示，粗糙模型和精细模型之间的应力模式存在差异：粗糙模型的应力值较高，患者A和患者B的预测最大壁应力差异分别为30%和11%。本文提出了一种新的方法来重建动脉瘤模型的基础上使用几套MR图像。这使得不仅能够更准确地表示TAA的管腔，而且还能够考虑管腔内血栓的壁表面。
The thoracic aortic aneurysm (TAA) is a pathology that involves an expansion of the aortic diameter in the thoracic aorta, leading to risk of rupture. Recent studies have suggested that internal wall stress, which is affected by TAA geometry and the presence or absence of thrombus, is a more reliable predictor of rupture than the maximum diameter, the current clinical criterion. Accurate reconstruction of TAA geometry is a crucial step in patient-specific stress calculations. In this work, a novel methodology was developed, which combines data from several sets of magnetic resonance (MR) images with different levels of detail and different resolutions. Two sets of images were employed to create the final model, which has the highest level of detail for each component of the aneurysm (lumen, thrombus, and wall). A reference model was built by using a single set of images for comparison. This approach was applied to two patient-specific TAAs in the descending thoracic aorta. The results of finite element simulations showed differences in stress pattern between the coarse and fine models: higher stress values were found with the coarse model and the differences in predicted maximum wall stress were 30% for patient A and 11% for patient B. This paper presents a new approach to the reconstruction of an aneurysm model based on the use of several sets of MR images. This enables more accurate representation of not only the lumen but also the wall surface of a TAA taking account of intraluminal thrombus.