Effect of acute changes of serum phosphate on fibroblast growth factor (FGF)23 levels in humans
Effect of acute changes of serum phosphate on fibroblast growth factor (FGF)23 levels in humans
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DOI：
10.1007/s00774-007-0779-3
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发表时间：
2007-11-01
影响因子：
3.3
通讯作者：
Fujita, Toshiro
中科院分区：
文献类型：
--
作者：
Ito, Nobuaki;Fukumoto, Seiji;Fujita, Toshiro
成纤维细胞生长因子 (FGF)23 被确定为参与多种低磷血症疾病发展的体液因子。随后的研究表明FGF23是一种调节血清磷酸盐水平的激素。然而，FGF23的产生和血清水平是如何调节的仍不清楚。本研究旨在确定血清磷酸盐的急剧变化是否会调节人体 FGF23 水平。四名健康志愿者参与了这项研究。在磷酸盐输注研究中，磷酸氢二钾以10mEq/h的速率输注4小时，并在输注开始后长达6小时内测量血清FGF23水平。在碳水化合物研究中，摄入相当于 150g 葡萄糖的部分水解淀粉，并类似地测量 FGF23 水平 6 小时。磷酸盐输注显着增加，碳水化合物摄入显着降低血清磷酸盐水平。然而，FGF23 并没有因这些操作而改变。结论是血清磷酸盐的急剧变化不会改变健康人的 FGF23 水平。
Fibroblast growth factor (FGF)23 was identified as a humoral factor involved in the development of several hypophosphatemic diseases. Subsequent studies indicated that FGF23 is a hormone regulating serum phosphate level. However, it is still unknown how the production and serum level of FGF23 are regulated. This study was designed to determine whether acute changes of serum phosphate modulate FGF23 levels in human. Four healthy volunteers participated in the study. In the phosphate infusion study, dibasic potassium phosphate was infused at a rate of 10mEq/h for 4h, and serum FGF23 levels were measured for up to 6h after the start of the infusion. In the carbohydrate study, partially hydrolyzed starch corresponding to 150g glucose was ingested and FGF23 levels were measured similarly for 6h. Phosphate infusion significantly increased and carbohydrate ingestion decreased serum phosphate levels, respectively. However, FGF23 did not change by these maneuvers. It is concluded that acute changes of serum phosphate do not modify FGF23 levels in the healthy human.