Fast multislice pH-weighted chemical exchange saturation transfer (CEST) MRI with Unevenly segmented RF irradiation.
Fast multislice pH-weighted chemical exchange saturation transfer (CEST) MRI with Unevenly segmented RF irradiation.
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DOI：
10.1002/mrm.22628
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发表时间：
2011-02
影响因子：
3.3
通讯作者：
Sorensen, A. Gregory
中科院分区：
文献类型：
--
作者：
Sun, Phillip Zhe;Cheung, Jerry S.;Wang, Enfeng;Benner, Thomas;Sorensen, A. Gregory
化学交换饱和转移(CEST)磁共振成像是一种通过稀释的CEST不稳定基团测量微环境特性的通用成像技术。传统上，CEST MRI采用长射频照射模块，然后进行快速图像采集以获得稳定的CEST对比度。然而，常规CEST MRI方法的灵敏度、扫描时间和空间覆盖可能并不是最优的。我们的研究提出了一种分段射频标记方案，该方案包括一个长一次射频照射模块，用于在图像采集后立即产生稳定的CEST对比度和重复的短二次射频照射模块，以保持稳定的CEST对比度，用于多切片采集和信号平均。改进的CEST磁共振成像方法通过组织状pH体模进行了实验验证，并针对最大对比度噪声比(CNR)进行了优化。此外，通过pH加权的内源性酰胺质子转移(APT)磁共振成像对所提出的序列进行了评价，显示出与常规APT MRI相似的对比度。综上所述，开发了一种快速的多层松弛自补偿CEST MRI序列，并显著提高了敏感性。
Chemical exchange saturation transfer (CEST) MRI is a versatile imaging technique for measuring microenvironment properties via dilute CEST labile groups. Conventionally, CEST MRI is implemented with a long RF irradiation module, followed by fast image acquisition to obtain the steady state CEST contrast. Nevertheless, the sensitivity, scan time and spatial coverage of the conventional CEST MRI method may not optimal. Our study proposed a segmented RF labeling scheme that includes a long primary RF irradiation module to generate the steady state CEST contrast and repetitive short secondary RF irradiation module immediately after the image acquisition so as to maintain the steady state CEST contrast for multi-slice acquisition and signal averaging. The proposed modified CEST MRI method was validated experimentally with a tissue-like pH phantom, and optimized for the maximal contrast-to-noise ratio (CNR). In addition, the proposed sequence was evaluated for imaging ischemic acidosis via pH-weighted endogenous amide proton transfer (APT) MRI, which showed similar contrast as conventional APT MRI. In sum, a fast multi-slice relaxation self-compensated CEST MRI sequence was developed, with significantly improved sensitivity.
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使用化学交换饱和转移 (CEST) MRI 对 pH 进行成像：校正伴随的 RF 辐射效应以量化 CEST MRI 的化学交换率和 pH
影响因子：
3.3
作者：
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通讯作者：
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影响因子：
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