Associations of triglyceride levels with longevity and frailty: A Mendelian randomization analysis.
Associations of triglyceride levels with longevity and frailty: A Mendelian randomization analysis.
复制标题
甘油三酯水平与长寿和虚弱的关联：孟德尔随机分析。
DOI：
10.1038/srep41579
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发表时间：
2017-01-30
影响因子：
4.6
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Liu Z;Burgess S;Wang Z;Deng W;Chu X;Cai J;Zhu Y;Shi J;Xie X;Wang Y;Jin L;Wang X
观察性研究表明甘油三酯水平与长寿和虚弱有关。本研究旨在检验这些关联是否具有因果关系。我们使用的数据来自如皋长寿和老龄化研究，这是一项在中国如皋进行的基于人群的队列研究。APOA 5基因区域的变体（rs662799）被用作遗传工具。进行孟德尔随机化（MR）分析，以检查遗传预测甘油三酯与两种衰老表型-长寿（≥95岁）和虚弱（改良Fried虚弱表型和罗克伍德虚弱指数）的相关性。rs662799的C等位基因与对照组中较高的甘油三酯水平显著相关（每个等位基因β = 0.301 mmol/L，p < 0.001），F统计量为95.3，R2 = 0.040。然而，MR分析未提供有力证据证明遗传预测的甘油三酯水平与长寿概率之间存在关联（OR：0.61; 95% CI：甘油三酯每增加1 mmol/L，0.35，1.07）。在老龄组（70-84岁）中，遗传预测的甘油三酯水平与虚弱指数（β = 0.008; 95% CI：-0.013，0.029）或虚弱表型（OR：1.91; 95% CI：0.84，4.37）无关。总之，目前缺乏足够的证据支持甘油三酯水平与老年人群的长寿和虚弱的因果关系。
Observational studies suggest associations of triglyceride levels with longevity and frailty. This study aimed to test whether the associations are causal. We used data from the Rugao Longevity and Ageing Study, a population-based cohort study performed in Rugao, China. A variant in the APOA5 gene region (rs662799) was used as the genetic instrument. Mendelian randomization (MR) analyses were performed to examine the associations of genetically predicted triglycerides with two ageing phenotypes – longevity ( ≥95 years) and frailty (modified Fried frailty phenotype and Rockwood frailty index). C allele of rs662799 was robustly associated with higher triglyceride levels in the comparison group (β = 0.301 mmol/L per allele, p < 0.001), with an F statistic of 95.3 and R2 = 0.040. However MR analysis did not provide strong evidence for an association between genetically predicted triglyceride levels and probability of longevity (OR: 0.61; 95% CI: 0.35, 1.07 per 1 mmol/L increase in triglycerides). In the ageing arm (70–84 years), genetically predicted triglyceride levels were not associated with the frailty index (β = 0.008; 95% CI: −0.013, 0.029) or the frailty phenotype (OR: 1.91; 95% CI: 0.84, 4.37). In conclusion, there is currently a lack of sufficient evidence to support causal associations of triglyceride levels with longevity and frailty in elderly populations.