Overexpression of GLUT1 correlates with Kras mutations in lung carcinomas
Overexpression of GLUT1 correlates with Kras mutations in lung carcinomas
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DOI：
10.3892/mmr.2011.736
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发表时间：
2012-03-01
影响因子：
3.4
通讯作者：
Fujii, Yoshitaka
中科院分区：
文献类型：
--
作者：
Sasaki, Hidefumi;Shitara, Masayuki;Fujii, Yoshitaka
葡萄糖是细胞能量的主要来源，葡萄糖转运蛋白1（GLUT1）是最常见的葡萄糖转运蛋白。GLUT1在几种肿瘤中有异常表达。从基因表达的微阵列和系列分析（SAGE）的结果，GLUT1转录表达被发现在克隆与突变Kras等位基因。我们推测GLUT1过表达可能与日本肺癌的临床病理特征相关。对来自名古屋市立大学医院的283例手术治疗的非小细胞肺癌（NSCLC）病例进行GLUT 1免疫组化。纳入36例Kras突变癌病例。GLUT1在138例（48.8%）肺癌患者中呈高表达。GLUT1过表达状态与性别显著相关（女性31.9% vs.男性54.5%，P
Glucose is the major source of energy for cells, and glucose transporter 1 (GLUT1) is the most common glucose transporter. GLUT1 has been found to be aberrantly expressed in several tumor types. From the results of the microarray and serial analysis of gene expression (SAGE), GLUT1 transcript expression was found to be higher in clones with mutant Kras alleles. We hypothesized that GLUT1 overexpression might be correlated with clinicopathological features of Japanese lung cancers. Immunohistochemistry for GLUT1 was performed in 283 surgically treated non-small cell lung cancer (NSCLC) cases from Nagoya City University Hospital. Thirty-six Kras mutant carcinoma cases were included. GLUT1 overexpression was found in 138 (48.8%) lung cancer patients. The GLUT1 overexpression status was significantly correlated with gender (women 31.9% vs. men 54.5%, P