Conditioned taste aversions and drugs of abuse: A reinterpretation
Conditioned taste aversions and drugs of abuse: A reinterpretation
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DOI：
10.1037/0735-7044.111.1.129
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发表时间：
1997-02-01
影响因子：
1.9
通讯作者：
Grigson, PS
中科院分区：
文献类型：
--
作者：
Grigson, PS
一项新的假说(和支持数据)为25年来的悖论提供了解决方案，在这个悖论中，积极强化的滥用药物也支持条件性味觉厌恶(CTA)。结果表明，与LiCl诱导的CTA不同，吗啡和可卡因对条件刺激(CS)的抑制依赖于味觉CS的奖赏特性。这一发现驳斥了CTA长期以来支持新的报酬比较账户的解释。也就是说，大鼠在味觉药物配对后减少了味觉CS的摄入量，因为CS的价值被一种高度强化的精神活性药物的价值所盖过。因此，CS摄入量的抑制是有充分证据的积极强化的结果，而不是假想的滥用药物的厌恶性质的结果。
A new hypothesis (and supporting data) provides a solution to the 25-year-old paradox whereby positively reinforcing drugs of abuse also support a conditioned taste aversion (CTA). The results show that unlike LiCl-induced CTAs, morphine- and cocaine-induced suppression of conditioned stimulus (CS) intake depends on the rewarding properties of the gustatory CS. This finding argues against the long-standing CTA interpretation in favor of a new reward comparison account. That is, rats decrease intake of a gustatory CS following taste-drug pairings because the value of the CS is outweighed by that of a highly reinforcing psychoactive drug. Suppression of CS intake, then, is a consequence of the well-documented positive reinforcing, rather than the hypothetical aversive, properties of drugs of abuse.