Can tissue surface tension drive somite formation?
Can tissue surface tension drive somite formation?
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DOI：
10.1016/j.ydbio.2007.04.032
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发表时间：
2007-07-15
影响因子：
2.7
通讯作者：
Schnell, Santiago
中科院分区：
文献类型：
--
作者：
Grima, Ramon;Schnell, Santiago
体节发生的流行模型认为，前减数分裂中胚层是由一个时钟和波前机制分割成体节。在分割过程中，间充质细胞进行压实，然后从其余的preomitic中胚层和随后的形态学变化，导致圆形体节的假定体节的分离。我们调查的可能性，最小化的组织表面张力驱动体节雕刻过程。考虑到体节形成的时间和组织的高体积粘度，我们发现组织的形状和形式通常只会发生很小的变化，通过组织表面张力驱动的细胞运动。这对于斑马鱼的体节发生尤其如此。因此，这些过程不太可能是体节形成的唯一和主要驱动力。我们提出了一个简单的趋化机制，加上高度的粘附力可以解释分配给体节形成的时间的形态学变化。(c)2007年爱思唯尔公司All rights reserved.
The prevailing model of somitogenesis supposes that the presomitic mesoderm is segmented into somites by a clock and wavefront mechanism. During segmentation, mesenchymal cells undergo compaction, followed by a detachment of the presumptive somite from the rest of the presomitic mesoderm and the subsequent morphological changes leading to rounded somites. We investigate the possibility that minimization of tissue surface tension drives the somite sculpting processes. Given the time in which somite formation occurs and the high bulk viscosities of tissues, we find that only small changes in shape and form of tissue typically occur through cell movement driven by tissue surface tension. This is particularly true for somitogenesis in the zebrafish. Hence it is unlikely that such processes are the sole and major driving force behind somite formation. We propose a simple chemotactic mechanism that together with heightened adhesion can account for the morphological changes in the time allotted for somite formation. (c) 2007 Elsevier Inc. All rights reserved.