Materials and Device Designs for Wireless Monitoring of Temperature and Thermal Transport Properties of Wound Beds during Healing.
Materials and Device Designs for Wireless Monitoring of Temperature and Thermal Transport Properties of Wound Beds during Healing.
复制标题
用于无线监测愈合过程中伤口床温度和热传输特性的材料和设备设计。
DOI：
10.1002/adhm.202302797
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发表时间：
2024
影响因子：
10
通讯作者：
Rogers,JohnA
中科院分区：
文献类型：
--
作者：
Ryu,Hanjun;Song,JosephW;Luan,Haiwen;Sim,Youngmin;Kwak,SungSoo;Jang,Hokyung;Jo,YoungJin;Yoon,Hong-Joon;Jeong,Hyoyoung;Shin,Jaeho;Park,DoYun;Kwon,Kyeongha;Ameer,GuillermoAntonio;Rogers,JohnA
慢性伤口是糖尿病患者的主要健康风险。这种伤口的再生需要在几个月或更长的时间内定期进行医疗治疗。监测愈合过程的方案可以为患者和护理者提供重要的反馈。虽然恶臭或发烧等定性指标可以提供一些间接信息，但对伤口床的定量测量有可能产生重要的见解。这项工作介绍了一种无线系统的材料和工程设计，该系统可以在整个愈合过程中连续捕捉伤口的时空温度和热传输信息。系统的实验和计算研究确立了这项技术的材料方面和基本能力。活体研究表明，温度和这个量的变化都提供了关于伤口状态的信息，以及最初的放热反应和疤痕组织形成机制的迹象。可生物吸收材料是这种设备版本的基础，这种设备可以绕过物理移除的风险，在伤口处和伤口内进行监测。
Chronic wounds represent a major health risk for diabetic patients. Regeneration of such wounds requires regular medical treatments over periods that can extend for several months or more. Schemes for monitoring the healing process can provide important feedback to the patient and caregiver. Although qualitative indicators such as malodor or fever can provide some indirect information, quantitative measurements of the wound bed have the potential to yield important insights. The work presented here introduces materials and engineering designs for a wireless system that captures spatio‐temporal temperature and thermal transport information across the wound continuously throughout the healing process. Systematic experimental and computational studies establish the materials aspects and basic capabilities of this technology. In vivo studies reveal that both the temperature and the changes in this quantity offer information on wound status, with indications of initial exothermic reactions and mechanisms of scar tissue formation. Bioresorbable materials serve as the foundations for versions of this device that create possibilities for monitoring on and within the wound site, in a way that bypasses the risks of physical removal.