ADENOSQUAMOUS CARCINOMA OF THE PANCREAS - A CLINICOPATHOLOGICAL STUDY
ADENOSQUAMOUS CARCINOMA OF THE PANCREAS - A CLINICOPATHOLOGICAL STUDY
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DOI：
10.1002/jso.2930470210
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发表时间：
1991-06-01
影响因子：
2.5
通讯作者：
ENJOJI, M
中科院分区：
文献类型：
--
作者：
YAMAGUCHI, K;ENJOJI, M
本文对八例胰腺腺鳞癌进行了临床病理学研究。 组织化学和免疫组织化学研究也进行了。 8例胰腺癌患者中男4例，女4例，平均年龄56岁，比其他胰腺癌患者小9岁。 肿瘤的起源部位和大小与一般胰腺癌相似。 组织学上，所有8个肿瘤都显示出腺癌和鳞状细胞癌之间的突然转变。 鳞状细胞癌位于肿瘤周围。 组织化学和免疫组织化学揭示了这两种成分的不同性质。 8例患者的累积1年生存率为21.4%，而72例胰腺腺癌患者的累积1年生存率为42.1%。 8例腺鳞癌患者的生存曲线明显低于36例胰腺高分化腺癌患者。 这些事实支持胰腺腺鳞癌中的鳞状细胞癌是既存腺癌的鳞状细胞化生的观点。 胰腺腺鳞癌的临床过程是不利的。
A total of eight patients with adenosquamous carcinoma of the pancreas were studied clinicopathologically. Histochemical and immunohistochemical studies were also done. The 8 patients were composed of 4 men and 4 women with a mean age of 56 years, which was 9 years younger than for other pancreatic carcinoma. The site of origin and size of the tumors were similar to those of usual pancreatic carcinoma. Histopathologically, all eight tumors showed an abrupt transition between adenocarcinoma and squamous cell carcinoma. Squamous cell carcinoma was located at the periphery of the tumors. Histochemistry and immunohistochemistry disclosed a different nature for both components. The cumulative 1-year survival rate of the 8 patients was 21.4%, compared to 42.1% of 72 with adenocarcinoma of the pancreas. The survival curve of the 8 patients with adenosquamous carcinoma was significantly less favorable than that of 36 patients with well-differentiated adenocarcinoma of the pancrease. These facts support the view that squamous cell carcinoma in adenosquamous carcinoma of the pancreas is squamous cell metaplasia of the pre-existing adenocarcinoma. The clinical course of adenosquamous carcinoma of the pancreas was unfavorable.