Ephaptic coupling of cardiac cells through the junctional electric potential
Ephaptic coupling of cardiac cells through the junctional electric potential
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DOI：
10.1007/s00285-008-0157-3
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发表时间：
2008-08-01
影响因子：
1.9
通讯作者：
Keener, James P.
中科院分区：
文献类型：
--
作者：
Copene, Elizabeth D.;Keener, James P.
心脏细胞通过间隙连接通道电耦合，间隙连接通道允许离子电流在细胞间从一个细胞传播到下一个细胞。此外，心肌细胞可能通过相邻细胞之间的连接间隙中的电势偶联。我们开发和分析的数学模型，两个细胞耦合通过一个共同的交界裂隙电位。与更详细的模型一致，我们发现耦合机制是高度依赖于参数的。我们的模型的分析表明，有两个时间尺度涉及，慢子系统的动力学提供了新的数学洞察耦合机制如何工作。我们发现，有两种不同类型的传播失败，我们能够表征参数空间到区域的传播成功和两种不同类型的传播失败。
Cardiac cells are electrically coupled through gap junction channels, which allow ionic current to spread intercellularly from one cell to the next. In addition, it is possible that cardiac cells are coupled through the electric potential in the junctional cleft space between neighboring cells. We develop and analyze a mathematical model of two cells coupled through a common junctional cleft potential. Consistent with more detailed models, we find that the coupling mechanism is highly parameter dependent. Analysis of our model reveals that there are two time scales involved, and the dynamics of the slow subsystem provide new mathematical insight into how the coupling mechanism works. We find that there are two distinct types of propagation failure and we are able to characterize parameter space into regions of propagation success and the two different types of propagation failure.