The thermoregulation of the nude mouse.
The thermoregulation of the nude mouse.
复制标题
裸鼠的体温调节。
DOI：
10.1159/000163251
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
W. Weihe
中科院分区：
文献类型：
--
作者：
W. Weihe
尽管感染性疾病已被根除，但裸鼠（nu/nu）的预期寿命仍低于有毛杂合子小鼠（nu/+）。裸鼠常发生消耗综合征，与并发感染有关。由于已经报道了多种内分泌改变[6]，因此出现了一个问题，即消瘦是否可能是由于进行性神经内分泌衰竭导致的产热能力下降。与nu/+小鼠的23-24 C相比，推荐26-28 C和40- 60%RH的高环境温度用于维持裸鼠[1]。如果甲状腺功能下降，即使这些亚热带温度对于裸鼠来说也可能太低而无法维持其热平衡。
In spite of the eradication of infectious dis eases, the life expectancy of nude mice (nu/nu) remains lower than that of the hairy heterozygous mice (nu/+). A wasting syn drome usually develops in nude mice which has been related to intercurrent infections. Since multiple endocrine alterations have been reported [6], the question arises as to whether wasting could result from a dimin ished heat production capacity due to progres sive neuroendocrine failure. High ambient temperatures of 26-28 C and 40-60% RH are recommended for the maintenance of nude mice compared to 23-24 C for nu/+ mice [1], It is possible that even these subtropical temperatures are too low for the nude mice to sustain their heat balance if diminished thy roid function occurs.