Correlation of LAPTM4B Polymorphisms With Cervical Carcinoma
Correlation of LAPTM4B Polymorphisms With Cervical Carcinoma
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作者：
Meng, Fanling;Song, Hongtao;Lou, Ge
背景：溶酶体相关蛋白跨膜4 β（LAPTM4B）是一种新的癌蛋白，在几种肿瘤中过表达。先前的研究表明，LAPTM4B多态性有助于某些类型癌症的风险。本研究旨在探讨LAPTM 4B等位基因与宫颈癌发病风险的关系。方法：对317例宫颈癌患者和416例对照者进行病例对照分析。从所有参与者的外周血淋巴细胞中提取基因组DNA。采用聚合酶链反应测定LAPTM4B基因型。使用非条件logistic回归模型计算比值比和95%置信区间（CI）。结果：两组比较差异有显著性（P
BACKGROUND: Lysosome-associated protein transmembrane 4 beta (LAPTM4B), a novel oncoprotein, is overexpressed in several carcinomas. Previous studies revealed that LAPTM4B polymorphisms contribute to the risk of certain types of cancers. The purpose of this study was to investigate the association between different LAPTM4B alleles and the risk of cervical carcinoma. METHODS: A case-control analysis was performed in 317 patients with cervical cancer and 416 control subjects. Genomic DNA was extracted from peripheral blood lymphocytes in all participants. LAPTM4B genotypes were determined using polymerase chain reaction. Odds ratios and 95% confidence intervals (CIs) were computed using an unconditional logistic regression model. RESULTS: There was a significant difference (P