Relationship between tonsils and IgA nephropathy as well as indications of tonsillectomy
Relationship between tonsils and IgA nephropathy as well as indications of tonsillectomy
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DOI：
10.1111/j.1523-1755.2004.00486.x
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发表时间：
2004-04-01
影响因子：
19.6
通讯作者：
Gejyo, F
中科院分区：
文献类型：
--
作者：
Xie, YS;Chen, XM;Gejyo, F
虽然有许多文章分别关于伊加肾病（IgAN）和扁桃体，但关于扁桃体，扁桃体炎，扁桃体切除术和IgAN之间的关系的综述有限。本文介绍了扁桃体的结构、发育和功能，IgAN与非IgAN扁桃体的区别，扁桃体伊加与肾小球伊加的一致性，扁桃体刺激、扁桃体感染和扁桃体切除对IgAN的影响。扁桃体切除术可改善泌尿系表现，维持肾功能稳定，改善系膜增生和伊加存款，对部分IgAN患者的长期肾存活有良好影响，且不引起明显的免疫缺陷，不增加上呼吸道感染的发生率，可作为一种潜在的有效治疗方法。IgAN患者扁桃体切除术的适应证主要包括扁桃体感染后泌尿系检查结果恶化、轻、中度肾损害。然而，扁桃体切除术可能是不够的，可能不会改变IgAN患者的预后显着肾损害。
Although there are many papers about IgA nephropathy (IgAN) and tonsils, respectively, reviews about the relationship between tonsils, tonsillitis, tonsillectomy, and IgAN are limited. In this review, we introduced the structure, development, and function of tonsils, difference of tonsils with and without IgAN, consistency of both tonsillar IgA and glomerular IgA, the effect of tonsil stimulation, tonsil infection, and tonsillectomy on IgAN showed some evidences in which tonsils were closely related to IgAN and polymeric IgA1 deposited in glomerular mesangium were at least in part of tonsillar origin. Tonsillectomy can improve the urinary findings, keep stable renal function, improve mesangial proliferation and IgA deposit, have a favorable effect on long-tern renal survival in some IgAN patients, and do not cause significant immune deficiency and do not increase incidence of the upper respiratory tract infections, and can be used as a potentially effective treatment. The indications of tonsillectomy in patients with IgAN include mainly the deterioration of urinary findings after tonsillar infection, mild or moderate renal damage. However, tonsillectomy may not be enough and may not change the prognosis in IgAN patients with marked renal damage.