Ranitidine in the treatment of duodenal ulceration.
Ranitidine in the treatment of duodenal ulceration.
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雷尼替丁治疗十二指肠溃疡。
DOI：
10.3109/00365528109181976
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发表时间：
1981
影响因子：
1.9
通讯作者：
K. Wormsley
中科院分区：
文献类型：
--
作者：
N. Peden;E. Boyd;J. Saunders;K. Wormsley
在一项随机、双盲、内镜对照的临床试验中，40例十二指肠溃疡患者接受雷尼替丁（320 mg/天）或西咪替丁（800 mg/天）治疗28天。两个治疗组的溃疡愈合率（雷尼替丁78%，西咪替丁45%）无显著差异。在随后的一项“开放”研究中，雷尼替丁（150毫克，每日两次）治疗了19名患者，治疗了28天，其中79%的患者溃疡愈合。雷尼替丁治疗没有明显的不良反应，对胃分泌能力没有持久的影响。然而，在西咪替丁治疗期间，血清睾酮的基础水平显著升高，而在雷尼替丁治疗期间没有观察到这种升高。结论雷尼替丁治疗十二指肠溃疡安全有效。
In a randomized, double-blind, endoscopically controlled clinical trial, 40 patients with duodenal ulcer were treated with either ranitidine (320 mg/day) or cimetidine (800 mg/day) for 28 days. The rate of healing of the ulcers (ranitidine, 78%, cimetidine, 45%) did not differ significantly in the two treatment groups. In a subsequent 'open' study, ranitidine (150 mg twice daily) healed the ulcers of 79% of 19 patients treated for 28 days. Treatment with ranitidine was not associated with significant adverse reactions and had no lasting effect on gastric secretory capacity. Whereas basal levels of serum testosterone rose significantly during treatment with cimetidine, no such increase was observed during treatment with ranitidine. We conclude that ranitidine can effectively and safely heal duodenal ulcers.