Does slowed processing speed account for executive deficits in multiple sclerosis? Evidence from neuropsychological performance and structural neuroimaging.
Does slowed processing speed account for executive deficits in multiple sclerosis? Evidence from neuropsychological performance and structural neuroimaging.
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处理速度减慢是否是多发性硬化症执行缺陷的原因？
DOI：
10.1037/a0037517
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发表时间：
2014
影响因子：
2.7
通讯作者：
Sumowski,JamesF
中科院分区：
文献类型：
--
作者：
Leavitt,VictoriaM;Wylie,Glenn;Krch,Denise;Chiaravalloti,Nancy;DeLuca,John;Sumowski,JamesF
目的观察多发性硬化症（MS）患者的执行力缺陷和处理速度慢（PS）。执行缺陷是否可以用慢速PS解释的问题用神经心理学测量和神经结构测量（脑萎缩）进行了检查。方法将50例MS患者与28例健康对照（hc）在有和没有PS元素的执行功能任务（如Trail Making Test和Wisconsin Card Sorting Test）进行比较。结果MS组在执行功能快速任务上的表现较hc组差。然而，在控制了速度之后，各组在执行任务上的差异消失了。在没有PS要求的执行任务上也没有组间差异。在MS组中评估疾病进展对执行任务绩效的影响。多发性硬化症参与者大脑萎缩程度越高，在快速执行任务上的表现越差，但在控制多发性硬化症后，这种联系消失了。在非快速执行任务上，大脑萎缩与表现之间没有联系。结论：sour的研究结果支持了MS的执行功能缺陷可以用慢速PS来解释的观点。这些发现强调了慢速PS作为其他认知功能的主要损害的作用。解开PS对执行功能的相对贡献是为MS患者制定适当的康复策略的重要一步。
ObjectiveExecutive deficits and slow processing speed (PS) are observed in persons with multiple sclerosis (MS). The question of whether executive deficits can be explained by slow PS was examined with neuropsychological measures and a neurostructural measure (brain atrophy).MethodFifty MS patients were compared with 28 healthy controls (HCs) on tasks of executive functioning with and without a PS element (eg, Trail Making Test and Wisconsin Card Sorting Test).ResultsThe MS group performed worse than HCs on speeded tasks of executive function. However, after controlling for speed, group differences on executive tasks disappeared. There were also no group differences on executive tasks with no PS demands. The effect of disease progression on executive task performance was assessed in the MS group. Higher atrophy in MS participants was associated with greater deficits on speeded executive tasks, but this association disappeared when controlling for PS. There was no association between atrophy and performance on nonspeeded executive tasks.ConclusionsOur results support the notion that executive deficits in MS may be explained by slow PS. These findings highlight the role of slowed PS as a primary impairment underlying other cognitive functions. Disentangling the relative contribution of PS to executive function is an important step toward the development of appropriate rehabilitation strategies for persons with MS.