Tumor Microenvironment on a Chip: The Progress and Future Perspective.
Tumor Microenvironment on a Chip: The Progress and Future Perspective.
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DOI：
10.3390/bioengineering4030064
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发表时间：
2017-07-21
期刊：
影响因子：
--
通讯作者：
Kim Y
中科院分区：
文献类型：
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作者：
Ahn J;Sei YJ;Jeon NL;Kim Y
肿瘤在其持续生长、侵袭和转移所需的复杂微环境中发展。肿瘤微环境在肿瘤的恶性或耐药性质中起着关键作用，成为有前途的治疗靶点。能够模拟肿瘤环境的微工程生理系统是一种新兴平台，其允许定量和可再现地表征具有病理生理学相关性的肿瘤反应。这篇综述强调了工程化肿瘤微环境系统的最新进展，这些系统能够对癌症进展和转移进行前所未有的机制检查。我们讨论了这些微工程仿生方法在抗癌药物预筛选应用中的进展和未来前景。
Tumors develop in intricate microenvironments required for their sustained growth, invasion, and metastasis. The tumor microenvironment plays a critical role in the malignant or drug resistant nature of tumors, becoming a promising therapeutic target. Microengineered physiological systems capable of mimicking tumor environments are one emerging platform that allows for quantitative and reproducible characterization of tumor responses with pathophysiological relevance. This review highlights the recent advancements of engineered tumor microenvironment systems that enable the unprecedented mechanistic examination of cancer progression and metastasis. We discuss the progress and future perspective of these microengineered biomimetic approaches for anticancer drug prescreening applications.