Living in CIN: Mitotic Infidelity and Its Consequences for Tumor Promotion and Suppression.
Living in CIN: Mitotic Infidelity and Its Consequences for Tumor Promotion and Suppression.
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DOI：
10.1016/j.devcel.2016.10.023
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发表时间：
2016-12-19
影响因子：
11.8
通讯作者：
Weaver BA
中科院分区：
文献类型：
--
作者：
Funk LC;Zasadil LM;Weaver BA
自1800年代末以来，有丝分裂期间染色体分离错误已被认为是肿瘤细胞的标志，从而产生了有丝分裂异常驱动肿瘤发生的长期假设。最近的研究表明，有丝分裂缺陷可以促进肿瘤，抑制它们，或两者都不做，这取决于染色体错误分离的速率。在这里，我们讨论了染色体错误分离的原因，它们对肿瘤发生和进展的影响，以及增加染色体错误分离率可能是一种有效的化疗策略的证据。
Errors in chromosome segregation during mitosis have been recognized as a hallmark of tumor cells since the late 1800s, resulting in the long-standing hypothesis that mitotic abnormalities drive tumorigenesis. Recent work has shown that mitotic defects can promote tumors, suppress them, or do neither, depending on the rate of chromosome missegregation. Here we discuss the causes of chromosome missegregation, their effects on tumor initiation and progression, and the evidence that increasing the rate of chromosome missegregation may be an effective chemotherapeutic strategy.