ENHANCEMENT OF ABSORPTION FROM THE INTACT AND TRANSECTED CANINE SMALL INTESTINE BY ELECTRICAL PACING
ENHANCEMENT OF ABSORPTION FROM THE INTACT AND TRANSECTED CANINE SMALL INTESTINE BY ELECTRICAL PACING
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通过电起搏增强完整和横断的犬小肠的吸收
DOI：
10.1016/0016-5085(79)90411-6
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发表时间：
1979
期刊：
影响因子：
29.4
通讯作者：
S. Phillips
中科院分区：
文献类型：
--
作者：
J. Collin;K. Kelly;S. Phillips
我们的目的是回答三个问题：逆行电起搏是否能增强完整空肠的吸收？便于起搏的十二指肠横断是否会减少空肠吸收？横断后起搏是否能增强肠吸收？在四只狗，一个75厘米的空肠段，以排除其管腔从肠流，但保持其肌电连续性与十二指肠起搏器通过桥的图尼卡肌层。记录和刺激电极被缝到节段上，并将输注导管插入其近端。恢复后，在每只狗中进行6个实验;在每一个100 mM-葡萄糖，90 mM-氯化钠溶液被注入到该节段的近端，在14.5 ml/5 min，和5 min的等分试样的流出物收集从远端造口3 hr. During第二个小时，通过远端双极电极给予电刺激。在完全横断和再吻合后重复实验。切断前，电刺激不改变起搏电位频率（x ± SE，17.9 ± 0.2次/min），但水、葡萄糖和钠的吸收增加（P < 0.05）。切断后起搏电位频率较切断前减慢（14.2 ± 0.3次/min，P < 0.001），但吸收无变化。起搏过程中，起搏器电位的夹带和反向传播，吸收大于切断前（P < 0.02）。我们的结论是，起搏完整的空肠增加空肠吸收，十二指肠横断不损害空肠吸收，横断有利于向后起搏，并增强吸收的完整的肠道。
Our aim was to answer three questions: Does retrograde electrical pacing enhance absorption from intact jejunum? Does duodenal transection, which facilitates pacing, reduce jejunal absorption? Does pacing after transection enhance absorption over that of intact bowel? In four dogs, a 75-cm segment of jejunum was constructed to exclude its lumen from the intestinal stream, but to preserve its myoelectric continuity with the duodenal pacemaker via a bridge of tunica muscularis. Recording and stimulating electrodes were sewn to the segment, and an infusion catheter was inserted into its proximal end. After recovery, six experiments were done in each dog; in each a 100 mM-glucose, 90 mM-NaCl solution was infused into the proximal end of the segment at 14.5 ml/5 min, and 5-min aliquots of effluent were collected from the distal stoma for 3 hr. During the second hour, electric stimuli were given via a distal bipolar electrode. The experiments were repeated after complete duodenal transection and reanastomosis. Before transection, electrical stimulation did not alter pacesetter potential frequency (x̄ ± SE, 17.9 ± 0.2 cycles/min), but absorption of water, glucose, and sodium was increased (P < 0.05). After transection, pacesetter potential frequency was slower than before transection (14.2 ± 0.3 cycles/min, P < 0.001), but absorption was unchanged. During pacing, entrainment and backward propagation of pacesetter potentials were achieved, and absorption was greater than before transection (P < 0.02). We conclude that pacing the intact jejunum increases jejunal absorption, that duodenal transection does not impair jejunal absorption, and that transection facilitates backward pacing and enhances absorption over that of intact bowel.