MR-Pathologic Comparison of the Upper Spinal Cord in Different Motor Neuron Diseases
MR-Pathologic Comparison of the Upper Spinal Cord in Different Motor Neuron Diseases
复制标题
不同运动神经元疾病上脊髓的 MR 病理比较
作者：
A. Sperfeld;V. Bretschneider;Leonie Flaith;A. Unrath;C. Hanemann;A. Ludolph;J. Kassubek
本MRI研究旨在评价运动神经元疾病亚组中脊髓的体内变化。对散发性肌萎缩侧索硬化症（ALS; n = 39）、散发性下运动神经元病（LMND; n = 19）、肯尼迪病（KD; n = 19）和对照组（n = 96）的颈胸脊髓进行标准MRI检查，分析脊髓信号变化和脊髓厚度。当ALS、LMND和对照组相互比较时，没有观察到厚度或信号改变的显著变化。然而，与所有其他组相比，在KD患者中，在颈部水平检测到显著的上脊髓萎缩。在胸部水平，与对照组和LMND相比，KD患者有显着的上脊髓萎缩。上脊髓明显萎缩似乎是KD相关的中枢-外周远端轴突病的特征。
This MRI study was performed to evaluate in vivo alterations of the spinal cord in defined subgroups of motor neuron diseases. Standard MRI examinations of the cervical and thoracic spinal cord in sporadic amyotrophic lateral sclerosis (ALS; n = 39), sporadic lower motor neuron disease (LMND; n = 19), Kennedy’s disease (KD; n = 19) and a control group (n = 96) were analyzed with respect to spinal cord signal changes and the thickness of the spinal cord. No significant changes in thickness or signal alterations were observed when comparing ALS, LMND and control groups with one another. However, in KD patients significant upper spinal cord atrophy was detected at the cervical level as compared with all other groups. At the thoracic level, KD patients had significant upper cord atrophy as compared with controls and LMND. Marked atrophy of the upper spinal cord seems to be a feature of the KD-associated central-peripheral distal axonopathy.