Preliminary evidence of low cortical GABA levels in localized 1H-MR spectra of alcohol-dependent and hepatic encephalopathy patients
Preliminary evidence of low cortical GABA levels in localized 1H-MR spectra of alcohol-dependent and hepatic encephalopathy patients
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DOI：
10.1176/ajp.156.6.952
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发表时间：
1999-06-01
影响因子：
17.7
通讯作者：
Krystal, JH
中科院分区：
文献类型：
--
作者：
Behar, KL;Rothman, DL;Krystal, JH
目的：这项研究的目的是比较健康受试者、最近脱毒的酒精依赖患者和肝性脑病患者大脑皮层中神经活性氨基酸的水平。方法：代谢产物水平测定在枕叶皮质通过使用空间定位的H-1-MRS。五个最近脱毒酒精依赖和5个肝性脑病患者酒精和非酒精相关疾病与10名健康受试者进行了比较。结果如下：γ-氨基丁酸（GABA）和高肌肽的组合水平在酒精依赖和肝性脑病患者中低于健康受试者。结论：酒精依赖和肝性脑病患者GABA能系统均发生改变。
Objective: The aim of the study was to compare levels of neuroactive amino acids in the cerebral cortex of healthy subjects, recently detoxified alcohol-dependent patients, and patients with hepatic encephalopathy. Method: Metabolite levels were measured in the occipital cortex by using spatially localized H-1-MRS. Five recently detoxified alcohol-dependent and five hepatic encephalopathy patients with alcohol and non-alcohol-related disease were compared with 10 healthy subjects. Results: The combined level of gamma-aminobutyric acid (GABA) plus homocarnosine was lower in the alcohol-dependent and hepatic encephalopathy patients than in the healthy subjects. Conclusions: The findings suggest that GABA-ergic systems are altered in both alcohol-dependent and hepatic encephalopathy patients.