Angiogenesis and neoplastic progression in vitro.
Angiogenesis and neoplastic progression in vitro.
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体外血管生成和肿瘤进展。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
P. Gullino
中科院分区：
文献类型：
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作者：
M. Ziche;P. Gullino
体内肿瘤转化风险高的细胞群已显示获得诱导新血管形成的能力。本实验检测了在体外肿瘤转化过程中是否发生了同样的变化。在四个细胞群（人HBL 100乳腺上皮细胞，BALB/c成纤维细胞，C57 BL-MG上皮细胞，和叙利亚金黄地鼠胚胎细胞），血管生成能力出现在他们的培养在体外，很久之前，肿瘤转化可以识别是明显的。这些数据被解释为支持这样的假设，即通常缺乏这种能力的细胞群获得血管生成能力表明肿瘤转化的风险增加。
In vivo cell populations at high risk of neoplastic transformation have been shown to acquire the ability to induce new formation of vessels. The present experiments tested whether the same change occurred during neoplastic transformation in vitro. In four cell populations (human HBL 100 mammary epithelium, BALB/c fibroblasts, C57BL-MG epithelium, and Syrian golden hamster embryo cells), angiogenic capacity appeared during their cultivation in vitro and was evident long before a neoplastic transformation could be recognized. The data were interpreted to support the hypothesis that acquisition of angiogenic capacity by a cell population normally devoid of this capacity indicates an increased risk of neoplastic transformation.