Genetic Risk Score Predicts Late-Life Cognitive Impairment.
Genetic Risk Score Predicts Late-Life Cognitive Impairment.
复制标题
DOI：
10.1155/2015/267062
复制
发表时间：
2015-01-01
影响因子：
4.7
通讯作者：
Erickson, Kirk I
中科院分区：
文献类型：
--
作者：
Wollam, Mariegold E;Weinstein, Andrea M;Erickson, Kirk I
介绍。阿尔茨海默病的家族史是其发病的重要危险因素，但与拥有多个风险等位基因相关的遗传风险仍然知之甚少。方法。在95名老年人（平均年龄为75.1岁，64.2%为女性）的样本中，我们基于BDNF、COMT和APOE中风险等位基因的积累构建了遗传风险评分。神经心理学评估和共识确定了认知状态（44例未受损，51例受损）。进行逻辑回归以确定遗传风险评分是否预测与每个基因相关的认知障碍。结果。当将个体基因多态性作为协变量纳入模型时，遗传风险评分增加与认知障碍风险增加近4倍相关（OR = 3.824, P = 0.013）。讨论。结合多种遗传影响的风险评分在预测晚年认知障碍方面可能比个体多态性更有用。
Introduction. A family history of Alzheimer's disease is a significant risk factor for its onset, but the genetic risk associated with possessing multiple risk alleles is still poorly understood. Methods. In a sample of 95 older adults (Mean age = 75.1, 64.2% female), we constructed a genetic risk score based on the accumulation of risk alleles in BDNF, COMT, and APOE. A neuropsychological evaluation and consensus determined cognitive status (44 nonimpaired, 51 impaired). Logistic regression was performed to determine whether the genetic risk score predicted cognitive impairment above and beyond that associated with each gene. Results. An increased genetic risk score was associated with a nearly 4-fold increased risk of cognitive impairment (OR = 3.824, P = .013) when including the individual gene polymorphisms as covariates in the model. Discussion. A risk score combining multiple genetic influences may be more useful in predicting late-life cognitive impairment than individual polymorphisms.