Reactive oxygen species in normal and tumor stem cells.
Reactive oxygen species in normal and tumor stem cells.
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DOI：
10.1016/b978-0-12-420117-0.00001-3
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发表时间：
2014
影响因子：
--
通讯作者：
Spitz, Douglas R.
中科院分区：
文献类型：
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作者：
Zhou, Daohong;Shao, Lijian;Spitz, Douglas R.
活性氧（ROS）在决定正常干细胞的命运中发挥着重要作用。干细胞需要低水平的ROS来维持静止和自我更新。 ROS 产生的增加会以剂量依赖性方式导致干细胞增殖/分化、衰老和凋亡，从而导致干细胞衰竭。因此，干细胞中ROS的产生受到严格调控，以确保它们在生物体的整个生命周期中具有维持组织稳态和修复受损组织的能力。在本章中，我们讨论正常干细胞中ROS的产生如何受到各种内在和外在因素的调节，以及在各种病理条件下ROS产生的失调如何改变这些细胞的命运。此外，还讨论了肿瘤干细胞异常产生ROS对肿瘤进展和治疗的影响。
Reactive oxygen species (ROS) play an important role in determining the fate of normal stem cells. Low levels of ROS are required for stem cells to maintain quiescence and self-renewal. Increases in ROS production cause stem cell proliferation/differentiation, senescence, and apoptosis in a dose-dependent manner, leading to their exhaustion. Therefore, the production of ROS in stem cells is tightly regulated to ensure that they have the ability to maintain tissue homeostasis and repair damaged tissues for the life span of an organism. In this chapter, we discuss how the production of ROS in normal stem cells is regulated by various intrinsic and extrinsic factors and how the fate of these cells is altered by the dysregulation of ROS production under various pathological conditions. In addition, the implications of the aberrant production of ROS by tumor stem cells for tumor progression and treatment are also discussed.