Risk of Second Primary Malignancies After External Beam Radiotherapy for Thyroid Cancer
Risk of Second Primary Malignancies After External Beam Radiotherapy for Thyroid Cancer
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DOI：
10.21873/anticanres.15605
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发表时间：
2022-03-01
影响因子：
2
通讯作者：
Megwalu, Uchechukwu C.
中科院分区：
文献类型：
--
作者：
Jin, Michael C.;Qian, Z. Jason;Megwalu, Uchechukwu C.
目的：探讨甲状腺癌患者体外放射治疗（EBRT）与第二原发肿瘤发生率的关系。材料和方法：数据来自监测、流行病学和最终结果9数据库。该研究队列包括1973年至2017年间诊断为甲状腺癌的患者。采用考克斯比例风险模型确定第二原发恶性肿瘤的危险因素。倾向评分匹配分析用于评估EBRT和第二原发恶性肿瘤之间的关联。结果：在72，392例甲状腺癌患者中，7，684例（10.6%）发生了继发性原发性恶性肿瘤。倾向评分匹配分析表明，接受EBRT的患者更有可能发生第二原发性恶性肿瘤[30年累积发生率=35.3%（95%置信区间（CI）=30.4-39.8% vs. 28.1%（95% CI=27.0-29.2%）;风险比=1.17（95% CI=1.03-1.33）]。结论：在甲状腺癌患者中，EBRT与第二原发恶性肿瘤的发病率增加有关。
Aim: To investigate the association between external beam radiotherapy (EBRT) and the incidence of second primary tumors in patients with thyroid cancer. Materials and Methods: Data were extracted from the Surveillance, Epidemiology, and End Results 9 database. The study cohort included patients diagnosed with thyroid cancer between 1973 and 2017. Risk factors for second primary malignancies were identified with Cox proportional hazards models. Propensity score-matched analyses were used to assess the association between EBRT and second primary malignancies. Results: Out of 72,392 patients with thyroid cancer, 7,684 (10.6%) developed a subsequent primary malignancy. Propensity score-matched analysis demonstrated patients receiving EBRT were more likely to develop second primary malignancies [30-year cumulative incidence=35.3% (95% confidence interval (CI)=30.4-39.8% vs. 28.1% (95% CI=27.0-29.2%); hazard ratio=1.17 (95% CI=1.03-1.33)]. Conclusion: In patients with thyroid cancer, EBRT is associated with an increased incidence of second primary malignancies.