AN IMMUNOHISTOCHEMICAL STUDY OF LEUKOCYTES IN HUMAN ENDOMETRIUM, 1ST AND 3RD TRIMESTER BASAL DECIDUA
AN IMMUNOHISTOCHEMICAL STUDY OF LEUKOCYTES IN HUMAN ENDOMETRIUM, 1ST AND 3RD TRIMESTER BASAL DECIDUA
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DOI：
10.1016/0165-0378(93)90025-d
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发表时间：
1993-01-01
影响因子：
3.4
通讯作者：
RANDIC, L
中科院分区：
文献类型：
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作者：
HALLER, H;RADILLO, O;RANDIC, L
对新鲜人子宫内膜和正常妊娠（无并发症）早期和晚期基底蜕膜活检标本进行了白细胞亚群的免疫组化定量研究。在子宫内膜和基底蜕膜的蜕膜基质中最突出的群体是巨噬细胞。偶见B细胞和γ/δ T细胞受体阳性细胞，散在分布于子宫内膜/蜕膜间质。CD 3+细胞在子宫内膜和前三个月基底蜕膜中的数量相对较少，但在妊娠晚期其数量增加（加倍）。与子宫内膜和晚期妊娠基底蜕膜相比，早期妊娠基底蜕膜中的CD 2+细胞略有增加。具有阳性NKH-1标志物（CD 56+）的细胞在前三个月显示出显著增加，而在后三个月，它们的数量急剧减少。CD 56：CD 3细胞比例在孕早期增加到5倍以上，而在孕晚期则急剧下降。上述妊娠早期CD 56+细胞和足月妊娠CD 3+细胞的增加表明这些细胞可能具有某些特定功能。然而，仍然需要确定所描述的在妊娠期间基底蜕膜中的蜕膜白细胞的数量变化对于胎儿同种异体移植物保护的机制是否具有任何重要性。
An immunohistochemical quantitative study of leucocyte subpopulations on fresh human endometrium and on biopsy specimens of first and third trimester basal decidua in normal (uncomplicated) pregnancies was performed. The most prominent population in endometrial and decidual stroma of basal decidua are macrophages. B cells as well as gamma/delta T cell receptor positive cells were found occasionally, scattered throughout the endometrial/decidual stroma. CD3+ cells were present in a relatively small number in the endometrium as well as in the first trimester basal decidua, but their number was elevated (doubled) in the third trimester of pregnancy. CD2+ cells showed a slight increase in first trimester basal decidua when compared with both endometrium and third trimester basal decidua. Cells with positive NKH-1 marker (CD56+) showed a significant increase in the first trimester, while in the third trimester their number diminished drastically. CD56:CD3 cell ratio increased to more than five times in first trimester basal decidua, while in the third trimester basal decidua decreased drastically. The mentioned increase of CD56+ cells in the first trimester and that of CD3+ cells at term suggests that these cells could have some specific function(s). However, it still has to be established whether the described quantitative changes of decidual leucocytes in basal decidua during pregnancy are of any importance for the mechanism(s) for the fetal allograft protection.