Cardiac involvement in Behçet's disease.
Cardiac involvement in Behçet's disease.
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白塞氏病累及心脏。
DOI：
10.1159/000177401
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发表时间：
1997
期刊：
影响因子：
1.9
通讯作者：
G. Valesini
中科院分区：
文献类型：
--
作者：
S. Morelli;C. Perrone;L. Ferrante;A. Sgreccia;R. Priori;P. Voci;M. Accorinti;P. Pivetti;G. Valesini
为了评估Behçet病患者心脏受累的发生率和程度，并探讨可能导致心脏受累的可能原因，对30名Behçet病患者和30名正常对照组进行了M型、二维和多普勒超声心动图检查。此外，患者和对照组的血清中均检测到抗核抗体和抗心磷脂自身抗体。最后，对患者和历史对照组的人类白细胞抗原-B51阳性进行评估。50%的患者出现二尖瓣脱垂，30%的患者出现近端主动脉扩张。与对照组相比，这些异常的发生率有显著差异。两组左心功能参数相似。抗核抗体和抗心磷脂自身抗体的阳性率很低(7%)，组间无差异。82.7%的患者检测到了HLA-B51，而对照组为21.7%(P<；0.00001)。总之，这项研究表明Behçet病患者的心脏异常率很高。
To assess the prevalence and the extent of cardiac involvement in patients with Behçet's disease and to investigate the possible causes that may predispose to this involvement, 30 patients affected by Behçet's disease and 30 normal control subjects were submitted to M-mode, two-dimensional, and Doppler echocardiographic evaluation. Moreover, antinuclear and anticardiolipin autoantibodies were determined in the sera of both patients and control subjects. Finally, HLA-B51 positivity was assessed in the patients and in a historical control group. Mitral valve prolapse was observed in 50% and proximal aorta dilatation in 30% of the patients. There was a significant difference in the rate of these abnormalities in comparison with the control group. Left ventricular function parameters were similar between the two groups. The positivity rate of antinuclear and anticardiolipin autoantibodies was very low (7%), without differences between the groups. HLA-B51 was detected in 82.7% of the patients versus 21.7% in the control group (p < 0.00001). In conclusion, this study demonstrates a high rate of cardiac abnormalities in patients with Behçet's disease.