Gleaning Multicomponent T1 and T2 Information From Steady-State Imaging Data
Gleaning Multicomponent T1 and T2 Information From Steady-State Imaging Data
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DOI：
10.1002/mrm.21704
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发表时间：
2008-12-01
影响因子：
3.3
通讯作者：
Jones, Derek K.
中科院分区：
文献类型：
--
作者：
Deoni, Sean C. L.;Rutt, Brian K.;Jones, Derek K.
T（1）（DESPOT 1）和T（2）（DESPOT 2）的驱动平衡单脉冲观测是快速、准确和精确的纵向和横向弛豫时间的体素测定方法。然而，该方法的一个局限性是单组分松弛的固有假设。在各种生物组织中，特别是在人的白色物质（WM）和灰质（GM）中，松弛已经显示出更完整的特征在于两种或更多种松弛组分或种类的总和，每种组分或种类被认为与独特的微解剖结构域或水池相关联。不幸的是，这些组件上的体素，全脑的基础上的表征传统上受到不切实际的采集时间。在这项工作中，我们扩展了传统的DESPOT（1）和DESPOT（2）的方法，包括多组分松弛分析。在对新技术进行数值分析后，将其重新命名为T（1）/T（2）的多分量驱动平衡单脉冲观测。（mcDESPOT），全脑多组分T（1）和T（2）定量在体内得到证实，临床实际时间为16至30分钟。结果来自4名健康个体和2名原发性进行性多发性硬化症（MS）患者证实了该方法用于识别和评估与几种神经退行性疾病相关的组织变化，特别是与WM相关的组织变化的未来潜力。Magn Reson Med 60：1372-1387，2008. (C)2008威利利斯公司
The driven-equilibrium single-pulse observation of T(1) (DESPOT1) and T(2) (DESPOT2) are rapid, accurate, and precise methods for voxelwise determination of the longitudinal and transverse relaxation times. A limitation of the methods, however, is the inherent assumption of single-component relaxation. In a variety of biological tissues, in particular human white matter (WM) and gray matter (GM), the relaxation has been shown to be more completely characterized by a summation of two or more relaxation components, or species, each believed to be associated with unique microanatomical domains or water pools. Unfortunately, characterization of these components on a voxelwise, whole-brain basis has traditionally been hindered by impractical acquisition times. In this work we extend the conventional DESPOT(1) and DESPOT(2) approaches to include multicomponent relaxation analysis. Following numerical analysis of the new technique, renamed multicomponent driven equilibrium single pulse observation of T(1)/T(2) (mcDESPOT), wholebrain multicomponent T(1) and T(2) quantification is demonstrated in vivo with clinically realistic times of between 16 and 30 min. Results obtained from four healthy individuals and two primary progressive multiple sclerosis (MS) patients demonstrate the future potential of the approach for identifying and assessing tissue changes associated with several neurodegenerative conditions, in particular those associated with WM. Magn Reson Med 60:1372-1387, 2008. (C) 2008 Wiley-Liss, Inc.