Altered resting-state hippocampal functional networks associated with chemotherapy-induced prospective memory impairment in breast cancer survivors.
Altered resting-state hippocampal functional networks associated with chemotherapy-induced prospective memory impairment in breast cancer survivors.
复制标题
乳腺癌幸存者静息态海马功能网络的改变与化疗引起的前瞻性记忆损伤相关
DOI：
10.1038/srep45135
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发表时间：
2017-03-22
影响因子：
4.6
通讯作者：
Wang K
中科院分区：
文献类型：
--
作者：
Cheng H;Li W;Gong L;Xuan H;Huang Z;Zhao H;Wang LS;Wang K
在这项研究中，我们的目的是探讨内在海马功能连接（FC）网络及其与前瞻性记忆的乳腺癌患者化疗诱导的认知障碍（CICI）。34名乳腺癌患者在辅助化疗前后（分别为CB和CC）和31名年龄和教育程度匹配的认知正常（CN）女性被招募，并接受前瞻性记忆任务和静息状态功能磁共振成像扫描。采用基于种子的功能连接分析比较CC组和CN组海马FC网络的差异。部分校正分析用于检查CC组中海马FC网络与前瞻记忆之间的关联。接受化疗的癌症组在简易精神状态检查、语言流畅性测试、数字广度和前瞻性记忆检查中的得分显著低于CN组。与CN组相比，CC组在额叶和顶叶皮质、楔前叶、后扣带回皮质和小脑中表现出增加的海马连接。此外，增加海马FC网络与前瞻记忆成绩呈负相关。这些发现表明，适应不良的海马功能作为一种机制的潜在损害前瞻性记忆的患者经历CICI。
In this study, we aimed to investigate the intrinsic hippocampal functional connectivity (FC) network and its relationship with prospective memory in patients with breast cancer suffering from chemotherapy-induced cognitive impairment (CICI). Thirty-four breast cancer patients before and after adjuvant chemotherapy (CB and CC, respectively) and 31 age- and education-matched cognitively normal (CN) women were recruited and subjected to a prospective memory task and a resting-state functional magnetic resonance imaging scan. Seed-based functional connectivity analysis was used to compare the hippocampal FC networks between CC and CN groups. Partial correction analysis was used to examine the association between the hippocampal FC network and prospective memory in the CC group. The cancer group that underwent chemotherapy obtained significantly poorer scores than the CN group on mini-mental state examination, verbal fluency test, digit span, and prospective memory examination. Compared to the CN group, CC group showed increased hippocampal connectivity in the frontal and parietal cortex, precuneus, posterior cingulate cortex, and the cerebellum. In addition, the increasing hippocampal FC networks were negatively correlated with prospective memory performance in the CC group. These findings suggest maladaptive hippocampal functioning as a mechanism underlying the impairment of prospective memory in patients experiencing CICI.