New hope: the emerging role of 5-hydroxymethylcytosine in mental health and disease.
New hope: the emerging role of 5-hydroxymethylcytosine in mental health and disease.
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DOI：
10.2217/epi-2016-0020
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发表时间：
2016-07
期刊：
影响因子：
3.8
通讯作者：
Andy Madrid;L. Papale;Reid S. Alisch
中科院分区：
文献类型：
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作者：
Andy Madrid;L. Papale;Reid S. Alisch
历史上，生物医学研究已经研究了遗传对心理健康的影响，但这些方法受到限制，可能是由于脑相关疾病的广泛遗传性（例如，30-90%）。表观遗传修饰，如DNA甲基化，是环境敏感的机制，可能在精神疾病的起源和进展中发挥作用。最近，5-羟甲基胞嘧啶（5 hmC）的全基因组破坏与早期和晚期精神疾病（如自闭症和阿尔茨海默病）的发展有关，为精神病学领域带来了新的希望。在这里，我们回顾了最近的联系，5 hmC精神疾病和讨论的背景下，其有前途的临床意义的5 hmC几个假定的功能。
Historically biomedical research has examined genetic influences on mental health but these approaches have been limited, likely due to the broad heritability of brain-related disorders (e.g., 30-90%). Epigenetic modifications, such as DNA methylation, are environmentally sensitive mechanisms that may play a role in the origins and progression of mental illness. Recently, genome-wide disruptions of 5-hydroxymethylcytosine (5hmC) were associated with the development of early and late onset mental illnesses such as autism and Alzheimer's disease, bringing new hope to the field of psychiatry. Here, we review the recent links of 5hmC to mental illness and discuss several putative functions of 5hmC in the context of its promising clinical relevance.