Mutation rate is linked to diversification in birds
Mutation rate is linked to diversification in birds
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DOI：
10.1073/pnas.1007888107
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发表时间：
2010-11-23
影响因子：
11.1
通讯作者：
Bromham, Lindell
中科院分区：
文献类型：
--
作者：
Lanfear, Robert;Ho, Simon Y. W.;Bromham, Lindell
基因组进化如何影响生物谱系多样化的速度？最近的研究表明，基因组进化的总体速度与多样化的速度相关。如果这是真的，这一主张将对理解多样化的过程产生重要影响，并对使用DNA序列数据重建进化史产生影响。然而，这种关系的普遍性和原因尚未确定。本文利用来自64个鸟类科的19个基因、17 kb的DNA序列数据集，测试了分子进化速率与净多样化之间的关系。我们发现，鸟类的分子进化速率与净多样化呈正相关。使用7.6 kb的蛋白质编码DNA数据集，我们表明同义替代率，因此突变率，与净多样化相关。进一步的分析表明，突变率和净多样化之间的联系不太可能是与可能影响这两个数量的生活史变量相关的间接结果，这表明突变率和净多样化之间可能存在因果关系。
How does genome evolution affect the rate of diversification of biological lineages? Recent studies have suggested that the overall rate of genome evolution is correlated with the rate of diversification. If true, this claim has important consequences for understanding the process of diversification, and implications for the use of DNA sequence data to reconstruct evolutionary history. However, the generality and cause of this relationship have not been established. Here, we test the relationship between the rate of molecular evolution and net diversification with a 19-gene, 17-kb DNA sequence dataset from 64 families of birds. We show that rates of molecular evolution are positively correlated to net diversification in birds. Using a 7.6-kb dataset of protein-coding DNA, we show that the synonymous substitution rate, and therefore the mutation rate, is correlated to net diversification. Further analysis shows that the link between mutation rates and net diversification is unlikely to be the indirect result of correlations with life-history variables that may influence both quantities, suggesting that there might be a causal link between mutation rates and net diversification.