Internal-illumination photoacoustic computed tomography
Internal-illumination photoacoustic computed tomography
复制标题
DOI：
10.1117/1.jbo.23.3.030506
复制
发表时间：
2018-03-01
影响因子：
3.5
通讯作者：
Yao, Junjie
中科院分区：
文献类型：
--
作者：
Li, Mucong;Lan, Bangxin;Yao, Junjie
我们报告了一种光声计算机断层扫描（PACT）系统，该系统使用带有圆柱形漫射器的定制光纤来内部照明深层目标。 PACT 中的传统外部光照明通常将穿透深度限制在距离组织表面几厘米的范围内，这主要是由于从外到内沿着光传播路径的强烈光学衰减。相比之下，内部光照明与外部超声检测相结合，可以潜在地检测到更深的目标。与以往使用前视光纤的内部照明PACT实现不同，我们的内部照明PACT系统采用定制光纤，光纤尖端附有3厘米长的锥形针扩散器，可以均匀地照亮周围空间并大幅扩大视野。我们表征了内部照明分布和 PACT 系统性能。我们进行了组织模型和体内动物研究，以进一步证明使用内部照明优于外部照明的成像深度。我们对嵌入光学散射介质中的 7.5 厘米深的叶子目标和覆盖有 3.7 厘米厚的鸡组织的小鼠跳动的心脏进行了成像。我们的结果共同证明，内部光照明与外部超声检测相结合可能是提高 PACT 在大型动物和人类深层器官成像中的穿透深度的有用策略。 (c) 2018 年光电仪器工程师学会 (SPIE)
We report a photoacoustic computed tomography (PACT) system using a customized optical fiber with a cylindrical diffuser to internally illuminate deep targets. The traditional external light illumination in PACT usually limits the penetration depth to a few centimeters from the tissue surface, mainly due to strong optical attenuation along the light propagation path from the outside in. By contrast, internal light illumination, with external ultrasound detection, can potentially detect much deeper targets. Different from previous internal illumination PACT implementations using forward-looking optical fibers, our internal-illumination PACT system uses a customized optical fiber with a 3-cm-long conoid needle diffuser attached to the fiber tip, which can homogeneously illuminate the surrounding space and substantially enlarge the field of view. We characterized the internal illumination distribution and PACT system performance. We performed tissue phantom and in vivo animal studies to further demonstrate the superior imaging depth using internal illumination over external illumination. We imaged a 7.5-cm-deep leaf target embedded in optically scattering medium and the beating heart of a mouse overlaid with 3.7-cm-thick chicken tissue. Our results have collectively demonstrated that the internal light illumination combined with external ultrasound detection might be a useful strategy to improve the penetration depth of PACT in imaging deep organs of large animals and humans. (c) 2018 Society of Photo-Optical Instrumentation Engineers (SPIE)