Intranasal immunization of mice with a mixture of the pneumococcal proteins PsaA and PspA is highly protective against nasopharyngeal carriage of Streptococcus pneumoniae
Intranasal immunization of mice with a mixture of the pneumococcal proteins PsaA and PspA is highly protective against nasopharyngeal carriage of Streptococcus pneumoniae
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DOI：
10.1128/iai.68.2.796-800.2000
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发表时间：
2000-02-01
影响因子：
3.1
通讯作者：
Hollingshead, SK
中科院分区：
文献类型：
--
作者：
Briles, DE;Ades, E;Hollingshead, SK
肺炎球菌通常是从携带者而不是从受感染的个体获得的。因此，为了诱导对肺炎链球菌的群体免疫，有必要引起对携带的保护。已知荚膜多糖-蛋白质缀合物PspA和PsaA对肺炎球菌的鼻咽携带有一定的保护作用，但并不总是完全消除携带。在这项研究中，我们观察到，PsaA引起更好的保护比PspA对运输。溶血素没有引起对运输的保护。用PsaA和PspA的混合物进行免疫接种引起了对携带的最佳保护。这些结果表明，PspA和PsaA可能是有用的，在人类中的群体免疫的启发。由于已知PspA和肺炎球菌溶血素引起对菌血症和肺炎的免疫，因此将其包含在粘膜疫苗中可以使这种疫苗能够预防侵袭性疾病以及携带。
Acquisition of pneumococci is generally from carriers rather than from infected individuals. Therefore, to induce herd immunity against Streptococcus pneumoniae it will be necessary to elicit protection against carriage. Capsular polysaccharide-protein conjugates, PspA, and PsaA are known to elicit some protection against nasopharyngeal carriage of pneumococci but do not always completely eliminate carriage. In this study, we observed that PsaA elicited better protection than did PspA against carriage. Pneumolysin elicited no protection against carriage. Immunization with a mixture of PsaA and PspA elicited the best protection against carriage. These results indicate that PspA and PsaA may be useful for the elicitation of herd immunity in humans. As PspA and pneumolysin are known to elicit immunity to bacteremia and pneumonia, their inclusion in a mucosal vaccine may enable such a vaccine to prevent invasive disease as well as carriage.