Tumor infiltrating lymphocytes in early breast cancer
Tumor infiltrating lymphocytes in early breast cancer
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DOI：
10.1016/j.breast.2017.03.010
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发表时间：
2018-02-01
期刊：
影响因子：
3.9
通讯作者：
Denkert, Carsten
中科院分区：
文献类型：
--
作者：
Pruneri, Giancarlo;Vingiani, Andrea;Denkert, Carsten
免疫编辑代表了一个涉及癌症和免疫系统细胞的复杂动态过程，由三个相互交织的阶段组成：消除、平衡和逃逸。涉及大量的免疫细胞亚型，每种亚型在与癌细胞相互作用中发挥着独特的作用：细胞毒性CD8(+) T细胞通过诱导肿瘤细胞死亡在杀伤癌症中发挥主要作用，而FOXP3(+) T调节细胞代表免疫抑制细胞亚型。 H&E 常规样本中肿瘤浸润淋巴细胞 (TIL) 的评估已被证明代表了乳腺癌 (BC) 患者（尤其是 Tripe 阴性和 HER2thorn 亚型）免疫抗肿瘤活性的可靠替代物和稳健的独立预后生物标志物。本综述讨论了乳腺癌免疫编辑的机制、其细胞复杂性和预后/预测相关性，提供了 TIL 代表 BC 患者最有希望的生物标志物之一的证据。 (c) 2017 Elsevier Ltd. 保留所有权利。
Immunoediting represents a complex and dynamic process involving cancer and immune system cells, composed by three intertwined phases: elimination, equilibrium and escape. A large number of immune cell subtypes are involved, each playing a peculiar role in interacting with cancer cells: cytotoxic CD8(+) T cells play a main role in cancer killing by inducing tumor cell death, while FOXP3(+) T-regulatory cells represent an immune-inhibitory cell subtype. The evaluation of tumor infiltrating lymphocytes (TILs) in H&E routine samples has been shown to represent a reliable surrogate of the immune anti-tumor activity and a robust independent prognostic biomarker in breast cancer (BC) patients, especially in the Tripe Negative and HER2thorn subtypes. The present review addresses the mechanisms of breast cancer immunoediting, its cell complexity and prognostic/predictive relevance, providing evidence that TILs represent one the most promising biomarkers for BC patients. (c) 2017 Elsevier Ltd. All rights reserved.