Sympathetic nervous system and blood pressure in humans: individualized patterns of regulation and their implications.
Sympathetic nervous system and blood pressure in humans: individualized patterns of regulation and their implications.
复制标题
人类的交感神经系统和血压：调节的个性化模式及其含义。
DOI：
10.1161/hypertensionaha.109.140186
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发表时间：
2010-07
期刊：
影响因子：
8.3
通讯作者：
Wallin, B. Gunnar
中科院分区：
文献类型：
--
作者：
Joyner, Michael J.;Charkoudian, Nisha;Wallin, B. Gunnar
自主神经系统及其交感神经臂在血压调节中起重要作用。1-3它们通过压力反射机制在血压的短期调节中的作用是众所周知的，特别是在对动脉压的瞬时变化的响应中。[4]然而，交感神经分支在长期（几天、几个月和几年）血压调节中的作用至少从20世纪70年代起就一直是争论的焦点。1，4我们在这篇高血压亮点中的目标是总结和整合我们对交感神经系统在人类长期血压调节中的作用的想法。1-3，5-9我们将主要关注来自人类研究的信息，并使用动物研究的数据来强调关键点。在这方面，我们要解决四个关键问题。前三个重点是我们最近的工作。最后一个问题是一个新出现的问题，更具投机性。首先，交感神经系统在血压正常的年轻男性（18- 40岁）长期血压调节中的作用是什么？第二，交感神经系统在长期血压调节中的作用是否随年龄而变化？第三，性别是否会影响交感神经系统在长期血压调节中的作用，性别差异是否会因年龄而改变？第四，我们是否正在进入一个由同情心驱动的高血压时代？在我们解决这些问题之前，我们分享一些关于如何评估人类交感神经整体活动的想法。
The autonomic nervous system and its sympathetic arm play important roles in the regulation of blood pressure. 1–3 Their role in the short-term regulation of blood pressure, especially in responses to transient changes in arterial pressure, via baroreflex mechanisms is well known. 4 However, the role of the sympathetic branch in longer-term (days, months, and years) blood pressure regulation has been a focus of debate since at least the 1970s. 1, 4 Our goal in this Hypertension Highlights is to summarize and integrate our ideas on the role of the sympathetic nervous system in long-term blood pressure regulation in humans. 1–3, 5–9 We will focus primarily on information from studies conducted in humans and use data from animal studies to emphasize key points. In this context, we want to address 4 key questions. The first 3 focus on our recent work. The final issue is an emerging one and more speculative. First, what is the role of the sympathetic nervous system in long-term blood pressure regulation in young (18-to 40-year–old) normotensive men? Second, does the role of the sympathetic nervous system in long-term blood pressure regulation change as a function of age in men? Third, does sex influence the role of the sympathetic nervous system in long-term blood pressure regulation, and are sex differences modified by aging? Fourth, are we entering an era of sympathetically driven hypertension? Before we address these questions, we share a few thoughts about how to assess the overall activity of sympathetic nerves in humans.