A triple-synergistic strategy for combinational photo/radiotherapy and multi-modality imaging based on hyaluronic acid-hybridized polyaniline-coated WS2 nanodots
A triple-synergistic strategy for combinational photo/radiotherapy and multi-modality imaging based on hyaluronic acid-hybridized polyaniline-coated WS2 nanodots
复制标题
基于透明质酸杂化聚苯胺涂覆 WS2 纳米点的组合光/放射治疗和多模态成像的三重协同策略
作者：
Wang Jinping;Pang Xiaojuan;Tan Xiaoxiao;Song Yilin;Liu Li;You Qing;Sun Qi;Tan Fengping;Li Nan
在这项研究中，我们报告了一种将透明质酸（HA）、聚苯胺（PANI）、WS2纳米点（WS2）和二氢卟酚e6（Ce6）整合到单个纳米平台（HA-WS2@PANI/Ce6）中的策略，用于肿瘤的荧光、光声和计算机断层扫描多模态成像引导的三模态光热/辐射/光动力学组合疗法。WS2纳米点核用作辐射增敏剂，PANI壳用作超热剂和光敏剂储库。HA和Ce6吸附在外壳上，分别用于肿瘤靶向和光动力学治疗。体内三峰成像显示HA-WS2@PANI/Ce6纳米颗粒在静脉注射后显示出增强的肿瘤摄取和诊断效果。更重要的是，在体外和体内实验中，纳米粒子表现出明显的近红外诱导光热效应，通过加速血液流动和随后增加肿瘤中的氧气供应，显著提高辐射和光动力学治疗效率。发现纳米杂化物对体外细胞和体内器官是安全的。综上所述，我们目前的工作展示了一种用于多模态成像引导的靶向三联疗法的纳米平台，这揭示了一种潜在的肿瘤治疗策略。
In this study, we report a strategy for integrating hyaluronic acid (HA), polyaniline (PANI), WS2 nanodots (WS2), and chlorin e6 (Ce6) into a single nanoplatform (HA-WS2@PANI/Ce6) for fluorescence, photoacoustic, and computed tomography multi-modality imaging-guided trimodal photothermal/radiation/photodynamic combination therapy of tumors. The WS2 nanodot core is used as the radiosensitizer with the PANI shell as the hyperthermal agent and the photosensitizer reservoir. HA and Ce6 were adsorbed on the outer shell for tumor targeting and photodynamic therapy, respectively. The in vivo trimodal imaging uncovered that HA-WS2@PANI/Ce6 nanoparticles showed enhanced tumor uptake and diagnosis effects after intravenous injection. More importantly, in the in vitro and in vivo experiments, the nanoparticles exhibited an evident near-infrared induced photothermal effect, which remarkably improved the radiation and photodynamic therapy efficiency by accelerating the blood flow and subsequently increasing oxygen supply in the tumor. The nanohybrids were found to be safe to cells in vitro and organs in vivo. Taken together, our current work demonstrates a nanoplatform for multimodal imaging guided targeted triple-therapy, which reveals a potential strategy for tumor treatment.