Diterpene Ginkgolides Exert an Antidepressant Effect Through the NT3-TrkA and Ras-MAPK Pathways
Diterpene Ginkgolides Exert an Antidepressant Effect Through the NT3-TrkA and Ras-MAPK Pathways
复制标题
二萜银杏内酯通过 NT3-TrkA 和 Ras-MAPK 途径发挥抗抑郁作用
DOI：
10.2147/dddt.s229145
复制
发表时间：
2020-03
期刊：
影响因子：
--
通讯作者：
Xie Peng
中科院分区：
文献类型：
--
作者：
Wang Ting;Bai Shunjie;Wang Wei;Chen Zhi;Xie Peng
Background Depression is a highly prevalent mental illness that severely impacts the quality of life of affected individuals. Our recent studies demonstrated that diterpene ginkgolides (DG) have antidepressant effects in mice. However, the underlying molecular mechanisms remained much unclear. Methods In this study, we assessed the antidepressant effects of chronic DG therapy in rats by evaluating depression-related behaviors, we also examined potential side effects using biochemical indicators. Furthermore, we performed an in-depth molecular network analysis of gene–protein–metabolite interactions on the basis of metabolomics. Results Chronic DG treatment significantly ameliorated the depressive-like behavioral phenotype. Furthermore, the neurotrophin signaling-related NT3-TrkA and Ras-MAPK pathways may play an important role in the antidepressant effect of DG in the hippocampus. Conclusion These findings provide novel insight into the mechanisms underlying the antidepressant action of DG, and should help advance the development of new therapeutic strategies for depression.
登录
查看更多内容
影响因子：
4.4
作者：
Wei Wang;Hua Guo;Shuxiao Zhang;Juan Li;K. Cheng;S. Bai;De-yu Yang;Haiyang Wang;Zihong Liang-Zih
通讯作者：
Wei Wang;Hua Guo;Shuxiao Zhang;Juan Li;K. Cheng;S. Bai;De-yu Yang;Haiyang Wang;Zihong Liang-Zih
影响因子：
3.9
作者：
Prakash Y;Thompson MA;Meuchel L;Pabelick CM;Mantilla CB;Zaidi S;Martin RJ
通讯作者：
Martin RJ
影响因子：
5.1
作者：
John Q. Wang;Q. Tang;Nikhil K. Parelkar;Zhenguo Liu;Shazia Samdani;E. Choe;Lu Yang;L. Mao
通讯作者：
John Q. Wang;Q. Tang;Nikhil K. Parelkar;Zhenguo Liu;Shazia Samdani;E. Choe;Lu Yang;L. Mao
影响因子：
8
作者：
Takeshi Nakamura;Reiko Sanokawa;Y. F. Sasaki;Dai Ayusawa;Michio Oishi;Nozomu Mori
通讯作者：
Takeshi Nakamura;Reiko Sanokawa;Y. F. Sasaki;Dai Ayusawa;Michio Oishi;Nozomu Mori
DOI：
10.1523/jneurosci.6314-11.2012
发表时间：
2012-03-21
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Sanchez-Ortiz E;Yui D;Song D;Li Y;Rubenstein JL;Reichardt LF;Parada LF
通讯作者：
Parada LF