Serum gamma-glutamyltransferase activity is increased in patients with calcific aortic valve stenosis.
Serum gamma-glutamyltransferase activity is increased in patients with calcific aortic valve stenosis.
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2008-07
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通讯作者：
H. Bozbaş;A. Yıldırır;Ozlem Demir;Abdulkadir Çakmak;E. Karacaglar;M. Yılmaz;S. Eroglu;B. Pirat;B. Ozin;H. Muderrisoglu
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作者：
H. Bozbaş;A. Yıldırır;Ozlem Demir;Abdulkadir Çakmak;E. Karacaglar;M. Yılmaz;S. Eroglu;B. Pirat;B. Ozin;H. Muderrisoglu
研究背景和目的越来越多的数据表明，血清γ-谷氨酰转移酶（GGT）活性（氧化应激增加的标志物）与心血管疾病之间存在独立的相关性。钙化性主动脉瓣疾病的过程已经显示出动脉粥样硬化的特征。本研究旨在评价血清GGT在钙化性主动脉瓣疾病患者中的可能作用。方法回顾性分析2005年1月至2010年12月我院超声心动图诊断主动脉瓣钙化性病变（主动脉瓣狭窄（AS）和主动脉瓣钙化（AVC），无明显狭窄）患者的超声心动图结果。随机选择年龄和性别匹配的主动脉瓣形态正常的患者作为对照组。共有383例患者入组研究（126例AS，133例AVC，124例对照）。血清GGT活性，沿着其他肝酶分析和实验室检查结果，进行了测定和组间比较。结果3组患者年龄、性别、临床及实验室检查结果相似。AS组、AVC组和对照组的中位血清GGT水平分别为23.0 U/l（平均值31.5 +/- 24.9 U/l）、22.0 U/l（平均值27.6 +/- 18.6 U/l）和18.0 U/l（平均值22.4 +/- 16.4 U/l）。与对照组相比，AS患者血清GGT和C-反应蛋白水平显著升高，而AVC患者与对照组之间这些参数的差异不显著。结论钙化性AS患者血清GGT活性增高。这些增加似乎发生在晚期而不是轻度钙化主动脉瓣疾病。
BACKGROUND AND AIM OF THE STUDY A growing body of data indicates an independent association between serum gamma-glutamyltransferase (GGT) activity, a marker of increased oxidative stress, and cardiovascular diseases. The process of calcific aortic valve disease has been shown to present characteristics of atherosclerosis. The study aim was to evaluate the possible role of serum GGT in patients with calcific aortic valve disease. METHODS The results of patients' echocardiography studies from 2005 for the presence of calcific aortic valve disease in the forms of aortic stenosis (AS) and aortic valve calcification (AVC) without significant valve stenosis, were retrospectively evaluated. Age-and gender-matched patients with normal aortic valve morphology were selected at random as a control group. A total of 383 patients was enrolled into the study (126 with AS, 133 with AVC, 124 controls). Serum GGT activity, along with other liver enzyme analyses and laboratory results, were determined and compared among the groups. RESULTS Age, gender and clinical and laboratory results were similar among the three groups. Median serum GGT levels in the AS, AVC and control groups were 23.0 U/1 (mean 31.5 +/- 24.9 U/1), 22.0 U/1 (mean 27.6 +/- 18.6 U/) and 18.0 U/l (mean 22.4 +/- 16.4 U/l), respectively. Compared to controls, AS patients had significantly higher serum GGT and C-reactive protein levels, while the differences between AVC patients and controls for these parameters were not significant. CONCLUSION The study results suggest that serum GGT activity is increased in patients with calcific AS. These increases seem to occur in advanced rather than milder forms of calcific aortic valve disease.