Contrast harmonic intravascular ultrasound - A feasibility study for vasa vasorum imaging
Contrast harmonic intravascular ultrasound - A feasibility study for vasa vasorum imaging
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DOI：
10.1097/01.rli.0000229773.11715.da
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发表时间：
2006-08-01
影响因子：
6.7
通讯作者：
van der Steen, Antonius F. W.
中科院分区：
文献类型：
--
作者：
Goertz, David E.;Frijlink, Martijn E.;van der Steen, Antonius F. W.
目的：我们试图研究的可行性，血管造影谐波intravascular ultrason.Methods的新技术的血管造影成像：原型血管内超声（IVUS）仪器开发的微泡造影剂的灵敏检测。该技术称为“谐波”成像，涉及以20 MHz（基波）发射超声并以40 MHz（二次谐波）检测对比信号。进行体模实验以研究在较大血管周围的壁中检测小血管。在动脉粥样硬化兔腹arthritas.Results：体模实验表明，改善小血管检测谐波模式相对于基波模式。对于体内实验，谐波成像通过统计学显著（P < 0.001）的图像功率增强实现了主动脉腔外造影剂的可视化，与外膜微血管的检测一致。这些微血管没有检测到在基本imaging model.Conclusions：这些结果表明对比谐波血管内超声作为一种新的技术血管vasorum成像的可行性。
Objective: We sought to investigate feasibility of vasa vasorum imaging using the novel technique of contrast harmonic intravascular ultrasound.Methods: Prototype intravascular ultrasound (IVUS) instrumentation was developed for the sensitive detection of microbubble contrast agents. The technique, "harmonic" imaging, involves transmitting ultrasound at 20 MHz (fundamental) and detecting contrast signals at 40 MHz (second harmonic). Phantom experiments were conducted to investigate the detection of a small vessel in the wall surrounding a larger vessel. In vivo experiments were conducted in atherosclerotic rabbit abdominal aortas.Results: The phantom experiments showed improved small vessel detection in harmonic mode relative to fundamental mode. For the in vivo experiments, harmonic imaging enabled the visualization of contrast agent outside the aortic lumen through a statistically significant (P < 0.001) enhancement of image power, consistent with the detection of adventitial microvessels. These microvessels were not detected in fundamental imaging mode.Conclusions: These results indicate the feasibility of contrast harmonic intravascular ultrasound as a new technique for vasa vasorum imaging.