Anger suppression mediates the relationship between optimism and natural killer cell cytotoxicity in men treated for localized prostate cancer.
Anger suppression mediates the relationship between optimism and natural killer cell cytotoxicity in men treated for localized prostate cancer.
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DOI：
10.1016/j.jpsychores.2005.08.001
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发表时间：
2006-04
影响因子：
4.7
通讯作者：
F. Penedo;Jason Dahn;David P. Kinsinger;M. Antoni;I. Molton;Jeffrey S. Gonzalez;M. Fletcher;B. Roos;C. Carver;N. Schneiderman
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文献类型：
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作者：
F. Penedo;Jason Dahn;David P. Kinsinger;M. Antoni;I. Molton;Jeffrey S. Gonzalez;M. Fletcher;B. Roos;C. Carver;N. Schneiderman
目的 本研究评估了 61 名接受局限性前列腺癌 (PC) 治疗的男性的乐观、抑郁、愤怒抑制和自然杀伤细胞毒性 (NKCC) 之间的关系。方法所有参与者均在单一时间点进行评估，测量人口统计、乐观、抑郁和愤怒抑制。我们还收集了外周静脉血来评估 NKCC。 结果结果显示，较高的乐观情绪与较高的 NKCC (β=.27，P<.05)、较少的抑郁症 (β=−.63，P<.001) 和较少的愤怒抑制 (β=−.29，P<.05) 相关。此外，较少的愤怒抑制（β=−.35，P<.01）与较高的 NKCC 相关。在控制抑郁和愤怒抑制的分层回归模型中，乐观与 NKCC 之间的关系变得不显着 [β=.18，t(56)=1.51，P=.14]，而愤怒抑制仍然与 NKCC 显着相关 [β=−.29，t(56)=−2.40，P<.05]。结论结果表明乐观与 NKCC 和更强的适应能力相关。表达愤怒。此外，较少的愤怒抑制似乎部分调节了乐观与 NKCC 之间的关系。
OBJECTIVEThis study evaluated relations among optimism, depression, anger suppression and natural killer cell cytotoxicity (NKCC) in 61 men treated for localized prostate cancer (PC).METHODAll participants were assessed at a single time point where demographics, optimism, depression and anger suppression were measured. We also collected peripheral venous blood to assess NKCC.RESULTSResults showed that greater optimism was associated with greater NKCC (β=.27, P<.05), less depression (β=−.63, P<.001) and less anger suppression (β=−.29, P<.05). Furthermore, less anger suppression (β=−.35, P<.01) was associated with greater NKCC. In a hierarchical regression model controlling for depression and then anger suppression, the relationship between optimism and NKCC became nonsignificant [β=.18, t(56)=1.51, P=.14], while anger suppression remained significantly correlated with NKCC [β=−.29, t(56)=−2.40, P<.05].CONCLUSIONSResults suggest that optimism is associated with NKCC and a greater ability to adaptively express anger. Furthermore, it appears that less anger suppression partially mediates the relationship between optimism and NKCC.