Power in voxel-based lesion-symptom mapping
Power in voxel-based lesion-symptom mapping
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DOI：
10.1162/jocn.2007.19.7.1067
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发表时间：
2007-07-01
影响因子：
3.2
通讯作者：
Schwartz, Myrna F.
中科院分区：
文献类型：
--
作者：
Kimberg, Daniel Y.;Coslett, H. Branch;Schwartz, Myrna F.
脑损伤人群中的病变分析补充了从功能性神经影像中学到的知识。基于体素的基于脑损伤人群中病变 - 行为相关性的方法越来越流行，并且有可能利用功能性磁共振成像绘制的图像分析方法。但是，对于这些研究，权力是一个主要问题，由于病变位置的分布，在区域上可能会有所不同。在这里，我们概述了基于体素的方法的一般考虑，表征了使用功能性神经成像改编的非参数置换测试的瓷砖使用，以及在病变研究中用于区域功率分析的当前方法。
Lesion analysis in brain-injured populations complements what can be learned from functional neuroimaging. Voxel-based approaches to mapping lesion-behavior correlations in brain-injured populations are increasingly popular, and have the potential to leverage image analysis methods drawn from functional magnetic resonance imaging. However, power is a major concern for these studies, and is likely to vary regionally due to the distribution of lesion locations. Here, we outline general considerations for voxel-based methods, characterize tile use of a nonparametric permutation test adapted from functional neuroimaging, and present methods for regional power analysis in lesion studies.