Assays for parathyroid hormone and their use in patients with end-stage renal disease.
Assays for parathyroid hormone and their use in patients with end-stage renal disease.
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甲状旁腺激素的测定及其在终末期肾病患者中的应用。
DOI：
10.1159/000067857
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发表时间：
2003
影响因子：
3
通讯作者：
Goodman,WilliamG
中科院分区：
文献类型：
--
作者：
Goodman,WilliamG
已经开发了新的第二代免疫测定PTH测定法。该检测方法仅测量全长生物活性PTH（1-84），不检测氨基末端截短的PTH片段，这是将其与第一代免疫测定PTH检测方法区分开来的特征。尽管迄今为止进行的研究很少，但在肾性骨营养不良患者的诊断评估中，第二代免疫测定PTH测定尚未显示出优于第一代测定的上级。使用第一代免疫测定PTH测定获得的血浆PTH水平继续为肾性骨病的管理提供最明确的指导，因为它们得到了丰富的骨组织学数据的支持。需要进一步研究第二代免疫测定PTH作为ESRD患者骨组织学预测因子的作用。
New second-generation immunometric PTH assays have been developed. The assays measure full-length biologically active PTH(1–84) exclusively and do not detect amino-terminally-truncated PTH fragments, a feature that distinguishes them from first-generation immunometric PTH assays. Although few studies have been done thus far, second-generation immunometric PTH assays have not been shown to be superior to first-generation assays for the diagnostic assessment of patients with renal osteodystrophy. Plasma PTH levels obtained using first-generation-immunometric PTH assays continue to provide the most definitive guide to the management of renal bone disease because they are supported by abundant bone histology data. Additional work is needed to further characterize the utility of second-generation immunometric PTH assays as predictors of bone histology in patients with ESRD.