Pre-fractionated microbial samples--the second generation natural products library at Wyeth.
Pre-fractionated microbial samples--the second generation natural products library at Wyeth.
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DOI：
10.3390/molecules13061406
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发表时间：
2008-06-20
期刊：
影响因子：
--
通讯作者：
Wagenaar MM
中科院分区：
文献类型：
--
作者：
Wagenaar MM
From the beginning of the antibiotic era in the 1940s to the present, Wyeth has sustained an active research program in the area of natural products discovery. This program has continually evolved through the years in order to best align with the “current” drug discovery paradigm in the pharmaceutical industry. The introduction of high-throughput screening and the miniaturization of assays have created a need to optimize natural product samples to better suit these new technologies. Furthermore, natural product programs are faced with an ever shortening time period from hit detection to lead characterization. To address these issues, Wyeth has created a pre-fractionated natural products library using reversed-phase HPLC to complement their existing library of crude extracts. The details of the pre-fractionated library and a cost-benefit analysis will be presented in this review.
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影响因子：
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作者：
Schmid, I;Sattler, I;Thiericke, R
通讯作者：
Thiericke, R
DOI：
10.1021/ci0200467
发表时间：
2003-01-01
期刊：
JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES
影响因子：
--
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
WARDLAW, JH
影响因子：
1.2
作者：
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通讯作者：
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