Reduced tolerance to digitalis-induced arrhythmias caused by coronary-flow alterations in isolated perfused heart of guinea pigs.
Reduced tolerance to digitalis-induced arrhythmias caused by coronary-flow alterations in isolated perfused heart of guinea pigs.
复制标题
豚鼠离体灌注心脏冠状动脉血流改变引起的洋地黄引起的心律失常的耐受性降低。
DOI：
10.1016/0024-3205(84)90580-0
复制
发表时间：
1984
期刊：
影响因子：
6.1
通讯作者：
Stemmer,PM
中科院分区：
文献类型：
--
作者：
Kim,DH;Akera,T;Kennedy,RH;Stemmer,PM
结扎冠状静脉主分支可提高离体灌流（Langendorff）豚鼠心脏对地高辛致心律失常作用的敏感性。逆行灌注研究表明，一个区域的存在与高细胞外K+浓度，邻近一个区域与正常K+浓度和暴露于糖苷，使心脏易于洋地黄诱导的毒性。该模型可用于研究急性心肌梗死降低强心苷治疗指数的机制。
The ligation of a main branch of coronary vein elevates the sensitivity of isolated, perfused (Langendorff) preparations of guinea-pig heart to arrhythmogenic actions of digoxin. Retrograde perfusion studies indicate that the presence of an area with a high extracellular K+concentration, adjacent to an area with normal K+concentration and exposed to the glycoside, predisposes the heart to digitalis-induced toxicity. This model may be useful in studying the mechanism by which acute myocardial infarction decreases the therapeutic index of cardiac glycosides.