Epidermal overexpression of stratum corneum chymotryptic enzyme in mice:: A model for chronic itchy dermatitis
Epidermal overexpression of stratum corneum chymotryptic enzyme in mice:: A model for chronic itchy dermatitis
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DOI：
10.1046/j.0022-202x.2001.01684.x
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发表时间：
2002-03-01
影响因子：
6.5
通讯作者：
Egelrud, T
中科院分区：
文献类型：
--
作者：
Hansson, L;Bäckman, A;Egelrud, T
炎症性皮肤病的病理生理学中涉及的组织特异性机制的鉴定可以提供新的可能性，以开发具有更少全身效应的有效疗法。丝氨酸蛋白酶角质层胰凝乳蛋白酶优先在角化上皮中表达。我们以前曾报道过银屑病角质层糜蛋白酶的表达增加。本文报道了在特应性皮炎的慢性病变中也发现角质层糜蛋白酶的表皮表达增加。发现在基底上表皮角质形成细胞中表达人角质层糜蛋白酶的转基因小鼠发生病理性皮肤变化，包括表皮厚度增加、角化过度、真皮炎症和严重瘙痒。结果表明，角质层糜蛋白酶可能参与炎症性皮肤病的发病机制，角质层糜蛋白酶和相关酶应作为新的治疗方法的潜在目标进行评估。
Identification of tissue-specific mechanisms involved in the pathophysiology of inflammatory skin diseases could offer new possibilities to develop effective therapies with fewer systemic effects. The serine protease stratum corneum chymotryptic enzyme is preferentially expressed in cornifying epithelia. We have previously reported on increased expression of the stratum corneum chymotryptic enzyme in psoriasis. Here is reported an increased epidermal expression of stratum corneum chymotryptic enzyme also found in chronic lesions of atopic dermatitis. Transgenic mice expressing human stratum corneum chymotryptic enzyme in suprabasal epidermal keratinocytes were found to develop pathologic skin changes with increased epidermal thickness, hyperkeratosis, dermal inflammation, and severe pruritus. The results suggest that stratum corneum chymotryptic enzyme may be involved in the pathogenesis of inflammatory skin diseases, and that stratum corneum chymotryptic enzyme and related enzymes should be evaluated as potential targets for new therapies.