Identification and Characterization of the First Ovothiol Biosynthetic Enzyme
Identification and Characterization of the First Ovothiol Biosynthetic Enzyme
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DOI：
10.1021/ja109378e
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发表时间：
2011-02-16
影响因子：
15
通讯作者：
Seebeck, Florian P.
中科院分区：
文献类型：
--
作者：
Braunshausen, Andrea;Seebeck, Florian P.
卵硫醇是组氨酸衍生的硫醇，其首先从海洋无脊椎动物中分离。我们已经确定了5-组氨酰半胱氨酸亚砜合酶（OvoA）作为第一个卵硫醇生物合成酶，其特征在于OvoA从塔斯马尼亚欧文氏菌和锥虫克氏锥虫。同源酶在从变形菌到动物的80多个基因组中编码。
Ovothiols are histidine-derived thiols that were first isolated from marine invertebrates. We have identified a 5-histidylcysteine sulfoxide synthase (OvoA) as the first ovothiol biosynthetic enzyme and characterized OvoAs from Erwinia tasmaniensis and Trypanosoma cruzi. Homologous enzymes are encoded in more than 80 genomes ranging from proteobacteria to animalia.