Comparison of participants and non-participants to the ORISCAV-LUX population-based study on cardiovascular risk factors in Luxembourg
Comparison of participants and non-participants to the ORISCAV-LUX population-based study on cardiovascular risk factors in Luxembourg
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DOI：
10.1186/1471-2288-10-80
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发表时间：
2010-09-07
影响因子：
4
通讯作者：
Guillaume, Michele
中科院分区：
文献类型：
--
作者：
Alkerwi, Ala'a;Sauvageot, Nicolas;Guillaume, Michele
背景：反应不佳是公共卫生调查的一个主要问题。在卢森堡大公国进行的一项以人群为基础的 ORISCAV-LUX 研究中，评估心血管危险因素，无反应率不容忽视。目前工作的目的是：1）调查研究样本对一般人群的代表性，2）比较参与者和非参与者的已知人口统计和心血管健康相关概况。方法：为了样本代表性，根据分层标准（年龄、性别和居住区）将参与者与源人群进行比较。根据“医政数据库”的补充信息，进一步分析评估健康状况是否影响应答率。在参与者和非参与者之间的单变量比较中使用了一些人口统计和发病率指标。结果：在联系参加研究的 4452 名潜在合格受试者中，最终有 1432 名（32.2%）参与者。与源人口相比，性别和地区分布没有发现差异。相比之下，样本中最年轻年龄组的代表性不足，而成年人和老年人的代表性过高，无论性别。在全球范围内，非参与者的调查临床概况与参与者相似。即使在控制年龄后，两组的入院率和心血管健康相关的医疗指标也具有可比性。与卢森堡居民相比，葡萄牙居民的参与率较低（OR = 0.58，95% CI：0.48-0.69）。它还与职业地位显着相关（P < 0.0001）。与其他职业类别的受试者相比，工人阶级的受试者对该研究的接受程度较低。 结论：ORISCAV-LUX 调查中获得的 32.2% 的参与率代表了此类多阶段、全国性、以人口为基础的调查的实际可实现率。它对应于计算样本量的预期速率。鉴于参与者和非参与者之间不存在区分健康状况的情况，可以得出结论，响应率不会使结果无效，并且可以将研究结果推广到人群。
Background: Poor response is a major concern in public health surveys. In a population-based ORISCAV-LUX study carried out in Grand-Duchy of Luxembourg to assess the cardiovascular risk factors, the non-response rate was not negligible. The aims of the present work were: 1) to investigate the representativeness of study sample to the general population, and 2) to compare the known demographic and cardiovascular health-related profiles of participants and non-participants.Methods: For sample representativeness, the participants were compared to the source population according to stratification criteria (age, sex and district of residence). Based on complementary information from the "medical administrative database", further analysis was carried out to assess whether the health status affected the response rate. Several demographic and morbidity indicators were used in the univariate comparison between participants and non-participants.Results: Among the 4452 potentially eligible subjects contacted for the study, there were finally 1432 (32.2%) participants. Compared to the source population, no differences were found for gender and district distribution. By contrast, the youngest age group was under-represented while adults and elderly were over-represented in the sample, for both genders. Globally, the investigated clinical profile of the non-participants was similar to that of participants. Hospital admission and cardiovascular health-related medical measures were comparable in both groups even after controlling for age. The participation rate was lower in Portuguese residents as compared to Luxembourgish (OR = 0.58, 95% CI: 0.48-0.69). It was also significantly associated with the professional status (P < 0.0001). Subjects from the working class were less receptive to the study than those from other professional categories.Conclusion: The 32.2% participation rate obtained in the ORISCAV-LUX survey represents the realistic achievable rate for this type of multiple-stage, nationwide, population-based surveys. It corresponds to the expected rate upon which the sample size was calculated. Given the absence of discriminating health profiles between participants and non-participants, it can be concluded that the response rate does not invalidate the results and allows generalizing the findings for the population.