Cerebellar, but not Motor or Parietal, High-Density Anodal Transcranial Direct Current Stimulation Facilitates Motor Adaptation
Cerebellar, but not Motor or Parietal, High-Density Anodal Transcranial Direct Current Stimulation Facilitates Motor Adaptation
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DOI：
10.1017/s1355617716000345
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发表时间：
2016-10-01
影响因子：
2.6
通讯作者：
Steinberg, Fabian
中科院分区：
文献类型：
--
作者：
Doppelmayr, Michael;Pixa, Nils Henrik;Steinberg, Fabian
目的：虽然运动适应是一个高度相关的过程，无论是日常生活以及康复，这个过程的许多细节仍然没有得到解决。为了评估初级运动（M1），顶叶和小脑区的运动适应过程的贡献，经颅直流电刺激（tDCS）已被应用。我们假设，小脑和M1的阳极刺激改善了镜像绘制的学习过程，这是一项涉及细粒度和空间组织良好的手部运动的任务。方法：高清晰度tDCS（HD-tDCS）允许局灶刺激来调节脑过程。在一项单次双盲研究中，我们比较了不同阳极刺激程序的效果。各组在小脑（CER）、右顶叶（PAR）或左侧M1接受刺激，并包括假手术组。参与者（n=83）必须完成几个镜像绘制任务之前，期间和之后的刺激。他们被要求尽可能快和准确地重新描绘一条五边形星星形状的线。已对跟踪时间（秒）和精度（偏差，mm）进行了评价。结果：结果表明，小脑HD-tDCS可以促进运动适应在一个单一的会话。M1处的刺激仅显示出增加运动适应的趋势，并且这些效应仅在刺激的第一部分期间可见。刺激与视觉空间处理相关的右顶叶区域并没有导致表现的提高。结论：运动适应在很大程度上依赖于小脑功能，HD-tDCS可加速这一过程。
Objectives: Although motor adaptation is a highly relevant process for both everyday life as well as rehabilitation many details of this process are still unresolved. To evaluate the contribution of primary motor (M1), parietal and cerebellar areas to motor adaptation processes transcranial direct current stimulation (tDCS) has been applied. We hypothesized that anodal stimulation of the cerebellum and the M1 improves the learning process in mirror drawing, a task involving fine grained and spatially well-organized hand movements. Methods: High definition tDCS (HD-tDCS) allows a focal stimulation to modulate brain processes. In a single-session double-blind study, we compared the effects of different anodal stimulation procedures. The groups received stimulation either at the cerebellum (CER), at right parietal (PAR), or at left M1, and a SHAM group was included. Participants (n=83) had to complete several mirror drawing tasks before, during, and after stimulation. They were instructed to re-trace a line in the shape of a pentagonal star as fast and accurate as possible. Tracing time (seconds) and accuracy (deviation in mm) have been evaluated. Results: The results indicated that cerebellar HD-tDCS can facilitate motor adaptation in a single session. The stimulation at M1 showed only a tendency to increase motor adaptation and these effects were visible only during the first part of the stimulation. Stimulating the right parietal area, relevant for visuospatial processing did not lead to increased performance. Conclusions: Our results suggest that motor adaptation relies to a great extent on cerebellar functions and HD-tDCS can speed up this process.